西酞普兰与阿米替林治疗帕金森病伴发抑郁对照研究

目的探讨西酞普兰治疗帕金森病伴发抑郁的临床效果和安全性。方法对52例帕金森病伴发抑郁的患者随机分为研究组和对照组,分别用西酞普兰和阿米替林治疗8周;用汉密顿抑郁量表(HAMD)评定临床疗效,用药物副反应量表(TESS)评定副反应。结果两组治疗2、4、8周末HAMD评分均明显低于治疗前,两组各时段评分相近(P<0.05或<0.01);两组治疗8周末的临床疗效相当(P>0.05);研究组治疗2、4、8周末TESS评分均明显低于对照组(P<0.05或P<0.01)。结论西酞普兰治疗帕金森病伴发抑郁的疗效较好,安全性好。

Comparison Study of the Treatment in Depressive Symptoms in Parkinson's Disease by Citalopran

Objective To compare the efficacy and safety of citalopran in the treatment of depressive symptoms in Parkinson＇s disease.Methods A total of 52 patients with depressive symptoms in Parkinson＇s disease were randomly into research group and control group,the research group was given Citalopran,and the control group was given amitriptyline.The study lasted 8 weeks.The clinical efficacy was evaluated using Hamilton Depression Scale（HAMD）.The side effects was assessed by the treatment emergent symptom scale（TESS）.Results The scores of HAMD were not significant differences between two groups after 2,4,8 weeks.The efficacy of research group after 8 weeks was similar to that of control group;The scores of TESS were significantly lower than those of the control group after 2,4,8 weeks.Conclusion The Citalopran and amitriptyline have similar effects on depressive symptoms in Parkinson＇s disease.However,Citalopran has less side effects.