度洛西汀与西酞普兰治疗脑卒中后抑郁焦虑共病对照研究

目的比较度洛西汀与西酞普兰治疗脑卒中后抑郁焦虑共病的疗效。方法对73例脑卒中后抑郁焦虑共病患者随机分为度洛西汀组和西酞普兰组,疗程6周。于治疗前及治疗1、2、4、6周采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,用副反应量表(TESS)评定副反应。结果治疗6周后两组HAMD和HAMA评分均显著下降(P<0.01),治疗1周末度洛西汀组疗效优于西酞普兰组(t=-2.312,-2.278;P均<0.05);治疗6周后度洛西汀组有效率为88.88%,西酞普兰组为86.48%,两组疗效差异无统计学意义(t=0.382,P>0.05);两组不良反应的发生率差异无统计学意义(P>0.05)。结论度洛西汀治疗脑卒中后抑郁焦虑疗效与西酞普兰相似,起效时间快于西酞普兰。

Comparison Study of Duloxetine and Citalopram in the Treatment of Post-stroke Comorbid Anxiety and Depression

Objective To compare the efficacy of duloxetine and citalopram in the treatment of post-stroke comorbid anxiety and depression.Methods A total of 73 patients meeting with criterion for post-stroke comorbid anxiety and depression were randomly divided into duloxetine group and citalopram group for 6 weeks treatment.They were assessed by Hamilton rating scale for depression（HAMD）,Hamilton rating scale for anxiety（HAMA）and Treatment emergent symptoms scale（TESS）before and after 1,2,4 and 6 weeks treatment.Results The scores of HAMD and HAMA decreased significantly after 6 weeks treatment for two groups（P0.01）.At the end of week 1,efficacy was superior in duloxetine group than in citalopram group（t=-2.312,-2.278;P0.05）.Response was found in 32（88.88%）patients in duloxetine group and 32（86.48%）patients in citalopram group at the end of 6 weeks treatment（t=0.382,P0.05）.There was no significantly differences in adverse events between two groups（P0.05）.Conclusion Duloxetine has the similar efficacy as citalopram in the treatment of post-stroke comorbid anxiety and depression,but the former takes effects quicker than the latter in the treatment.