抑郁症患者认知功能与脑源性神经营养因子相关性研究

目的探讨抑郁症患者认知功能及血清脑源性神经营养因子BDNF及其与抑郁严重程度的关系,为防治疾病提供重要依据。方法采用酶联免疫吸附法、汉密尔顿抑郁量表(HAMD)和威斯康星卡片分类(WCST)测验分别测定40例抑郁症患者的血清BDNF水平、抑郁严重程度及认知功能,并与49名正常对照组进行对比分析。结果研究组治疗前总应答数、非持续性错误数均明显增加,正确应答数明显减少,血清BDNF水平明显降低,与对照组比较有显著性差异(P<0.01)。研究组治疗8周末总应答数、持续性错误数、非持续性错误数减少,完成分类数和正确应答数增加,血清BDNF水平明显升高,HAMD总分明显降低,与治疗前比较有显著差异(P<0.05或P<0.01)。治疗前,患者组WCST非持续性错误与血清BDNF水平呈负相关(r=-0.34,P<0.05),血清BDNF水平与HAMD总分无相关(r=-0.10,P>0.05)。治疗后,WCST上述5个指标与血清BDNF水平及HAMD总分均无相关(P>0.05)。结论抑郁症患者存在认知功能受损及血清BDNF水平的下降,抗抑郁治疗可改善认知功能,并显著提高血清BDNF水平。

The Correlation Study on Cognitive Function and Brain-derived Neurotrophic Factor in Patients with Depression

Objective To investigate the relationship among serum brain derived neurotrophic factor(BDNF)and major depression and cognitive dysfunction.Methods Serum BDNF levels were measured in 40 depression and 49 healthy controls.The severities of depression and cognition function were measured with the 17-item Hamilton Rating Scale for Depression(HAMD-17)and the Wisconsin Card Sorting Test(WCST).Results The participants with depression had more non-perseverative responses and errors,and fewer conceptual level responses,and generated fewer categories on the WCST,and lower Serum BDNF levels than the controls(P<0.01),and so were the results of 8 weeks of treatment(P<0.05 or P<0.01),respectively.The number of non-perseverative errors on WCST was negatively correlated with a the levels of serum BDNF(r=-0.34,P<0.05)before the treatment,while the intensity of depressive symptoms had no relationship with the levels of serum BDNF(r=-0.10,P>0.05)after the treatment.Conclusion The patients with depression before treatment have worse executive function performance and lower Serum BDNF.Anti-depressive therapy can improve them.