中西医结合治疗慢性肺源性心脏病并心力衰竭的临床观察

目的观察卡托普利联合复方丹参中西医结合治疗慢性肺源性心脏病心力衰竭的临床疗效及安全性。方法选取吉林大学中日联谊医院收治的76例老年慢性肺源性心脏病心力衰竭患者,随机分为对照组及联合治疗组(观察组)各38例。两组患者均采取化痰平喘,控制呼吸道感染,利尿,纠正酸碱失衡,持续低流量吸氧及电解质紊乱加强营养支持等常规治疗;观察组在此基础上给予卡托普利每次12.5²5 mg,每日3次空腹口服,并予以复方丹参40 mL加5%葡萄糖注射液500 mL静脉滴注,每天1次,连用14 d。结果观察组在临床症状、体征改善,临床症状缓解时间方面均优于对照组;且观察组患者的血液流变学指标及血气分析指标,与对照组相比较都有明显的改善(P<0.05),观察组患者的6 min步行距离结果明显好于对照组患者(P<0.05)。观察组的总有效率(89.47%)显著高于对照组的总有效率(73.68%)(P<0.05)。结论卡托普利联合复方丹参注射液可以提高肺源性心脏病心力衰竭患者的临床疗效,经济安全,值得临床推广。

Observation of Therapeutic of Chronic Pulmonary Heart Disease Complicated with Heart Failure Conbined Treatment of Traditional Chinese Medicine and Western Medicine

Objective To discuss the therapeutic effect of administration of compound salvia miltionrrhiza injection and captopril as a therapy for chronic pulmonary heart disease complicated with heart failure. Methods 76 patients with chronic pulmonary heart disease complicated with heart failure selected in China-Japan Union Hospital of Jilin University, whose were randomly devided into the control group （n=38） and the combination therapy group （n=38）（observation group）. The two groups were treated with phlegm and asthma, control of respiratory infections, diuretic, correct acid-base imbalance, continuous low flow oxygen, electrolyte imbalance nutritional support and other conventional treatments. The observation group were used captopril 12.5~25 mg oral, 3 times a day, composite salvia miltiorrhiza injection 40 mL plused 5%glucose 500 mL, IV drip, 1 time a day on the basis of routine treatment. 14 days of continuous use. Results The clinical symptoms and signs and time aspects of clinical symptoms in the observation group were better than the control group;and the hemorheological parameters, blood gas analysis in the observation group were improved better than those in the control group （P〈0.05）, and the walking distance within 6 minutes in the observation group was longer than that in the control group （P〈0.05）. The overall efficiency in the observation group （89.47%） was significantly higher than the control group （73.68%） （P〈0.05）. Conclusions The combination of compound salvia miltionrrhiza injection and captopril could improve the clinical curative effect of chronic pulmonary heart disease complicated with heart failure, and treatment is better, worthy of promotion.