小白鼠对急性缺氧耐受性的昼夜节律

在昼夜10个时点,观察了模拟海拔10000m高原(大气压等于26.7kPa)急性缺氧60min时小白鼠活存数与死亡动物的活存时间。从凌晨3:00起,小白鼠活存数开始增加,死亡动物的活存时间开始延长,并于5∶30达到最高值。随后,活存数虽维持在同一水平,而死亡动物的活存时间则逐渐缩短。两者在14:56-0:30间处于最低值。结果表明:①小白鼠对急性缺氧的耐受性具有昼夜节律变化;②以夜间活动的啮齿类动物为实验研究对象时,应注意昼夜节律对研究结果的影响。

The Effects of circadian Rhythm on Tolerance to Acute Hypcxia in Mice

The relationship between circadian rhythm and tolerance to acute hypoxia at a Simula ted altitude of 10000m was studied in 110 micc.Bolh number of survival and surviving time were increased from 3: 00 and reached the hightidc at 5:00.From then the number of survival remained at the same level,the surviving time declined gradually.Both the number of survival and surviving time attained the lowest value at 14: 56 to 0:30.The results suggest: 1.there is a close relationship b etween circadian rhythm and tolerance to acutehypoxia; 2.when rodents arc used for this kind of study,the affect of circadian rhythm should be considered.