Influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season,Beijing, China |
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| Institution: | 1. Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China;2. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region;3. Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;4. Foundation for the Promotion of Health and Biomedical Research in the Valencia Region FISABIO – Public Health, Valencia, Spain;5. School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia;6. School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China;1. Instituto de Salud Pública de Navarra, IdiSNA–Navarra Institute for Health Research, Pamplona, Spain;2. CIBER Epidemiología y Salud Pública (CIBERESP), Spain;3. Complejo Hospitalario de Navarra, IdiSNA–Navarra Institute for Health Research, Pamplona, Spain;4. Clínica Universidad de Navarra, IdiSNA–Navarra Institute for Health Research, Pamplona, Spain;5. Centro Nacional de Microbiología (WHO National Influenza Centre–Madrid), Instituto de Salud Carlos III, Majadahonda, Spain;1. Guangzhou Center for Disease Control and Prevention, Guangzhou, China;2. Nanfang Hospital, Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou, China;3. Influenza Division, Centers for Disease Control and Prevention, Atlanta, United States;1. WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;2. WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia;3. Fielding School of Public Health, University of California, Los Angeles, USA;1. Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China;2. WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China;3. Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China;4. Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, China;5. Department of Pediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong Special Administrative Region, China;6. Centre of Influenza Research, The University of Hong Kong, Hong Kong Special Administrative Region, China;1. Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;1. Beijing Center for Disease Prevention and Control, Beijing, China;2. Beijing Research Center for Preventive Medicine, Beijing, China;3. Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA |
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| Abstract: | BackgroundVaccination is recommended to prevent influenza virus infection and associated complications. This study aimed to estimate the influenza vaccine effectiveness (VE) against hospitalization in the 2015/16 season in Beijing.MethodsPatients who were hospitalized in the 5 study hospitals between 1 Oct 2015 and 15 May 2016 were recruited. Influenza vaccination status was obtained for PCR-confirmed influenza patients and the selected controls who tested negative for the virus. Conditional logistic regression was used to estimate the influenza VE matching by calendar week, and adjusting for age, study sites, underlying medical conditions, smoking status, and hospital admissions over the past 12 months.ResultsThe overall VE was ?37.9% (95% CI: ?103.3, 6.5) against laboratory-confirmed influenza-associated hospitalization. The 2015–16 seasonal vaccine was had ?61.9% (95% CI: ?211.9, 15.9), ?5.4% (95% CI: ?108.1, 46.6) and ?45.2% (95% CI: ?152.6, 16.5) effectiveness to prevent infection from A(H1N1)pdm09, A(H3N2) and influenza B, respectively.ConclusionsInfluenza vaccination did not show effective protection against hospitalization with influenza in 2015/16 season in Beijing. |
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| Keywords: | Influenza Vaccine Effectiveness Test negative Hospitalization |
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