Cannabinoid Modulation of Amygdala Subregion Functional Connectivity to Social Signals of Threat |
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Authors: | Stephanie M. Gorka Daniel A. Fitzgerald Harriet de Wit K. Luan Phan |
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Affiliation: | Department of Psychiatry (Gorka and Fitzgerald, and Prof and Dr Phan), and Department of Psychology, University of Illinois, Chicago, IL (Gorka and Prof and Dr Phan); Jesse Brown VA Medical Center, Mental Health Service Line, Chicago, IL (Fitzgerald and Prof and Dr Phan); University of Chicago, Department of Psychiatry and Behavioral Neurosciences, Chicago, IL (Prof de Wit); University of Illinois, Chicago Anatomy and Cell Biology, Chicago, IL (Prof and Dr Phan). |
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Abstract: | Background:Δ9-Tetrahydrocannabinol has been shown to modulate anxiety and facilitate the extinction of fear by inhibiting amygdala reactivity. Since functional coupling between the amygdala and prefrontal cortex is implicated in affective processes, it is possible that Δ9-tetrahydrocannabinol affects amygdala-prefrontal cortex functional connectivity in ways that differ across amygdala subregions: basolateral, centromedial, and superficial.Methods:The aim of the study was to examine the effects of Δ9-tetrahydrocannabinol on functional connectivity between amygdala subregions and the prefrontal cortex during socio-emotional threat in healthy adults using a double-blind, placebo-controlled, within-subjects design. Sixteen subjects completed a functional magnetic resonance imaging task designed to probe amygdala responses to social threat. Amygdala subregion-prefrontal cortex functional connectivity was compared between Δ9-tetrahydrocannabinol and placebo using generalized psychophysiological interaction analyses.Results:Findings indicated that Δ9-tetrahydrocannabinol enhanced basolateral and superficial amygdala connectivity to the rostral anterior cingulate/medial prefrontal cortex.Conclusion:These effects, including Δ9-tetrahydrocannabinol’s potential ability to reduce threat perception or enhance socio-emotional regulation, may help understand the neurocircuitry of affect. |
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Keywords: | Δ 9-tetrahydrocannabinol, cannabis, social threat, functional connectivity |
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