Genistein improves thyroid function in Hashimoto’s thyroiditis patients through regulating Th1 cytokines |
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| Institution: | 1. Environmental and Experimental Pathology, Paulista University (UNIP), Rua Dr. Bacelar 1212, 4th Floor, 04026-002, São Paulo, SP, Brazil;2. Microbiology, Immunology and Parasitology Department, Federal University, Rua Sena Madureira 1500, 04021-001, São Paulo, SP, Brazil;3. Physiopathology Department, Butantan Institute, Rua Vital Brasil 1500, 05503-900, São Paulo, SP, Brazil;1. Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea;2. Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea;1. Department of Paediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy;2. Department of Maternal and Children’s Health, Obstetrics and Gynecology Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy;3. Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy;4. Department of Maternal and Children’s Health, Neonatal Intensive Care Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy;1. Department of Toxicology, School of public health, Zhejiang University School of Medicine, Hangzhou 310058, China;2. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China;3. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;4. The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 31000, China;5. Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310000, China;6. Blood center of Zhejiang Province, Hangzhou 310000, China;1. Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008 Lisboa, Portugal;2. CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. Universidade Técnica, 1300-477 Lisboa, Portugal;3. CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires de Pátria, 1169-056 Lisboa, Portugal;4. Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal;1. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street Rm MS409, Lexington, KY 40536, USA;2. Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, 789 S. Limestone Street Suite 292, Lexington, KY 40536, USA;3. Department of Internal Medicine, University of Kentucky College of Medicine, 900 S. Limestone Street Suite 303, Lexington, KY 40536, USA |
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| Abstract: | Hashimoto thyroiditis (HT) is a common autoimmune disease. Genistein is an isoflavone with immunomodulatory functions in various diseases. In this double-blind, randomized, placebo-controlled clinical study, we investigated the effects of genistein on patients with HT. A total of 218 patients were recruited. Genistein treated patients had a significant increased T4, fT4 levels, as well as reduction in serum TSH, TPOAb and TgAb levels, compared with those receiving placebo. Furthermore, Th1 related cytokine IFN-γ and IL-2 changes after genistein treatment suggest the immune modulating effect of genistein is mediated through regulating the function of Th1 cells. Overall, the genistein administration was effective and well tolerated in HT patients. These results demonstrate an immunological effect of genistein on HT patients. Further studies are warranted to determine the longer-term effects and possible chemopreventive effects on thyroid cancer in HT patients. |
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| Keywords: | Hashimoto thyroiditis (HT) Genistein Immunomodulatory |
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