| 高血压致认知功能障碍机制进展 |
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| 引用本文： | 柳君楠,张宏亮,林欣,白锋.高血压致认知功能障碍机制进展[J].安徽医药,2023,27(6):1065-1068. |
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| 作者姓名： | 柳君楠 张宏亮 林欣 白锋 |
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| 作者单位： | 兰州大学第二临床医学院，甘肃兰州，730030;兰州大学第二医院心内科，甘肃兰州 730030 |
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| 摘 要： | 随着社会、经济和医学的发展，人们的寿命得以延长，与老龄化相关的巨大挑战是脑血管病及认知功能损害两大疾病明显增多，给病人、家庭和社会带来负担。高血压是认知障碍的重要影响因素之一，高血压通过损害脑微循环的结构和功能完整性，破坏血脑屏障，引发神经炎症影响认知功能，以及长期高血压引起的脑小血管病包括白质高信号、腔隙性梗死和微出血，也会导致认知能力下降。目前多项研究表明适当的降压治疗在一定程度上能预防或延缓高血压病人的认知功能障碍。
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| 关 键 词： | 高血压 血管性认知功能障碍 脑白质病变 血压变异性 炎性因子 |
Advances in understanding the mechanisms of cognitive dysfunction caused by hypertension |
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| LIU Junnan,ZHANG Hongliang,LIN Xin,BAI Feng.Advances in understanding the mechanisms of cognitive dysfunction caused by hypertension[J].Anhui Medical and Pharmaceutical Journal,2023,27(6):1065-1068. |
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| Authors: | LIU Junnan ZHANG Hongliang LIN Xin BAI Feng |
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| Institution: | The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China;De partment of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China |
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| Abstract: | With developments in society, economy and medicine, people are living longer and aging is becoming an increasingly important issue worldwide. The subsequent huge challenge related to aging is the significant increase in the incidence and prevalence of two major diseases, cerebrovascular disease and cognitive impairment, which bring a burden to patients, families and society. Hypertension is an important influencing factor of cognitive impairment. Hypertension affects cognitive function by impairing the structural and |
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| Keywords: | Hypertension Vascular cognitive dysfunction Cerebral white matter lesions Blood pressure variability Inflammatory factors |
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