Severe underestimation of pertussis related hospitalizations and deaths in the Netherlands: A capture-recapture analysis |
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| Affiliation: | 1. Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands;2. Department of Paediatric Immunology and Infectious Diseases, University Medical Hospital Utrecht, Utrecht, The Netherlands;1. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China;2. Hangu Centers for Disease Control and Prevention, Tianjin 300480, China;1. National Center for Immunization Research and Surveillance of Vaccine Preventable Diseases, The Children''s Hospital at Westmead, Westmead, New South Wales, Australia;2. Discipline of Pediatrics and Child Health, University of Sydney, The Children''s Hospital at Westmead, Westmead, New South Wales, Australia;3. Department of Microbiology and Infectious Diseases, The Children''s Hospital at Westmead, Westmead, New South Wales, Australia;1. Univ. Lille, U1019, UMR 8204, CIIL – Centre for Infection and Immunity of Lille, F-59000 Lille, France;2. CNRS, UMR 8204, F-59000 Lille, France;3. Inserm, U1019, F-59000 Lille, France;4. CHU Lille, F-59000 Lille, France;5. Institut Pasteur de Lille, F-59000 Lille, France;1. Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan;2. Section of Pediatrics, Department of Medicine, Fukuoka Dental College, 2-15-1, Tamura, Sawara-ku, Fukuoka 814-0193, Japan;3. Department of Pediatrics, Kawasaki Medical School, 577, Matsushima, Kurashiki, Okayama 701-0192, Japan;4. Field Epidemiology Training Program, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan;5. Department of Preventive Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan;6. Sotobo Children''s Clinic, Medical Corporation Shigyo-no-kai, 1880-4, Izumi, Misaki-cho, Isumi 299-4503, Chiba, Japan;7. Clinical Epidemiology Research Center, Medical Co. LTA, 6-18, Ten-ya-machi, Hakata-ku, Fukuoka 812-0025, Japan;1. Ciber de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, España;2. Departamento de Salud Pública, Facultad de Medicina, Universidad de Barcelona, Barcelona, España |
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| Abstract: | OjectiveDespite vaccination, pertussis has remained endemic, sometimes leading to severe disease. We aimed to quantify the completeness of reporting (CoR) of pertussis hospitalizations and deaths in the Netherlands.Study designCoR was estimated using capture-recapture analyses. Hospitalizations (2007–2014) from the National Registration Hospital Care (hospital data) were matched to the notifiable Infectious Disease case registry (notifications) providing (month and) year of birth, gender and postal code. Deaths (1996–2014) from Statistics Netherlands (death registry) were matched to notifications using gender, age, year of death and notification date. Cases <2 years (y) and ≥2y were analysed separately. Chao’s estimator estimated the total population, which was used to calculate CoR.ResultsUsing strict matching criteria, we found 461 matches among 876 (hospital data) and 757 (notifications) hospitalizations <2y. The population estimate of hospitalized infants was 1446, resulting in CoR between 52% and 61%. For hospitalizations ≥2y (246; hospital data and 264; notifications) 43 matches were found, with a population estimate of 1512 and CoR between 16.5% and 22%.Among thirteen (death registry) and eight (notifications) deaths <2y, seven cases overlapped. The population estimate was 16. CoR of the two sources was 50–81%. With two (death registry) and eight (notifications) deaths ≥2y without overlap, the population estimate was 26 and CoR 8–31%.ConclusionResults showed substantial underestimation of pertussis hospitalizations and deaths. This has to be taken into account in evaluation of current and future immunization programs. |
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| Keywords: | Pertussis Whooping cough Vaccination Underestimation Hospitalization Death |
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