In vivo administration of TNF-{alpha} prevents EMC-M virus induced viral encephalitis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

In vivo administration of TNF-{alpha} prevents EMC-M virus induced viral encephalitis

Authors:	Sriram, Subramaniam Topham, David J. Carroll, Laurie Shenoy, Mohan Adesina, Adekunle Craighead, John E.

Affiliation:	Departments of Neurology, College of Medicine, University of Vermont Burlington, Vermont 05405, USA ¹ Departments of Pathology, College of Medicine, University of Vermont Burlington, Vermont 05405, USA

Abstract:	EMC-M virus causes a monophasic paralytic syndrome characterizedby encephalltic lesions in the brain and patchy demyellnatinglesions in the spinal cord and nerve roots of BALB/c mice. Sincethe replication of EMC virus in vitro is inhibited by tumornecrosis factor (TNF)- ${alpha}$ we have studied the effect of in vivoadministration of this cytokine on the acute disease. Our studiesshow that periodic administration of TNF- ${alpha}$ to animals infectedwith EMC-M reduces viral titers in the brain, and decreasesthe degree of clinical paralysis and the severityof the inflammatorylesions in the brain.

Keywords:	TNF- /math/alpha.gif" ALT=" {alpha}" BORDER=" 0" > EMC virus viral encephalitis
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