Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats |
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Authors: | Chen J C Tsai C C Chen L D Chen H H Wang W C |
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Institution: | Research Institute of Chinese Medicine, Chinese Medical College, Taichung, Taiwan. |
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Abstract: | Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities. |
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