Leptin level and its role in the regulation of reproductive function in females with anorexia nervosa

Objective To explore the relationship between serum leptin level and the hypothalamus-pituitary-gonad (HPG) axis in female adolescents with anorexia nervosa (AN). Methods Sixteen newly diagnosed female adolescents with AN in Shanghai and Zhejiang province were investigated, and their serum leptin, FSH, LH and body composition were measured before and after 18 weeks treatment, and their menorrhea cycles were observed. The rhythm of 24 h serum leptin secretion was studied in