Distribution and location of slowly adapting pulmonary stretch receptors in the airways of cats |
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| Authors: | K Ravi |
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| Affiliation: | 1. Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong, China;2. Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Key Laboratory of Mental Health of the Ministry of Education, Guangdong Province Key Laboratory of Psychiatric Disorders, Southern Medical University, Guangzhou 510515, Guangdong, China;3. Department of Rehabilitation, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong Province, China;4. Department of Orthopedics, Guangdong Provincial People''s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China;5. Department of Anesthesiology, Shenzhen People''s Hospital, Shenzhen, China;6. Department of Hyperbaric Oxygen Rehabilitation (Intensive Rehabilitation Center), Southern Theater Command General Hospital of PLA, Guangzhou 510010, Guangdong, China;1. Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York;2. Department of Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York;3. Department of Otolaryngology, Head and Neck Surgery, Mount Sinai West, Mount Sinai Health System, New York, New York;1. The Florey Department of Neuroscience & Mental Health, University of Melbourne, Parkville, Australia;2. Division of Pulmonary, Critical Care & Sleep, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA;1. Laboratoire des Systèmes Perceptifs, UMR 8248, CNRS, Paris, France;2. Département d’Etudes Cognitives, Ecole Normale Supérieure, PSL, Paris, France;3. UCL Ear Institute, London, UK;4. Edmond and Lily Safra Center for Brain Sciences and the Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel;1. Department of Pharmacology, Zhejiang Respiratory Drugs Research Laboratory, School of Basic Medical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China;2. Department of Pathogenic Biology and Immunology, Medical School of Southeast University, Nanjing 210009, China;3. Department of Pharmacy, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, China;4. Department of Pediatrics, The Affiliated Hangzhou First People''s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China;5. Institute of Dairy Science, MoE Key Laboratory of Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China;6. Department of Acupuncture and Moxibustion, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200021, China;7. Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, China;1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL;2. Department of Pulmonary Medicine, University of Salamanca, Salamanca, Spain;3. Department of Pulmonary Medicine, University of Granada, Granada, Spain |
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| Abstract: | The distribution and location of slowly adapting pulmonary stretch receptors (PSRs) that affect respiratory and cardiovascular functions were investigated in anaesthetized, artificially ventilated and thoracotomized cats. The location of the receptors was done by punctate stimulation and local mechanical stimulation after occlusion of the trachea at end-expiration (Exp). 84% of the slowly adapting PSRs were found to be located in the lung parenchyma. The occlusion technique alone was found to be of help only for a limited population of stretch receptors. The intrapulmonary distribution of PSRs revealed a greater percentage of receptors in the diaphragmatic lobe. No correlation was found between conduction velocity and receptor location. Both the slowly and rapidly conducting receptors were found to be scattered throughout the entire lung parenchyma. However, it was observed that while the majority of low threshold (LT) PSRs were located closer to the hilum of the lung, many of the higher threshold (HT) receptors were located farther away. In addition, when veratrine was administered into the pulmonary circulation, 83% of HT PSRs studied were stimulated by the drug, while only 25% of LT PSRs under study could be stimulated this way. The significance of the above findings is discussed. |
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