| IL-18基因启动子区-607C/A位点多态性与痛风发病相关性 |
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| 引用本文： | 王新凤,袁鹰,李长贵,刘世国.IL-18基因启动子区-607C/A位点多态性与痛风发病相关性[J].青岛大学医学院学报,2010,46(3):196-198,202. |
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| 作者姓名： | 王新凤 袁鹰 李长贵 刘世国 |
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| 作者单位： | 青岛大学医学院附属医院内分泌科,山东,青岛,266003 |
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| 摘 要： | 目的探讨山东汉族人白细胞介素-18(IL-18)基因启动子区-607C/A位点单核苷酸多态性与痛风易感性之间的关系。方法应用聚合酶链反应-序列特异性引物技术,检测100例痛风病人和100例非痛风病人IL-18基因启动子区-607C/A单核苷酸多态性位点的基因型。结果非痛风病人和痛风病人IL-18基因启动子区-607C/A位点3种基因型频率分别为:AA型0.18(18/100)、0.18(18/100),AC型0.58(58/100)、0.67(67/100),CC型0.24(24/100)、0.15(15/100)。IL-18基因启动子区-607C/A位点的基因型和等位基因频率在两组之间分布无明显差异。结论山东汉族人群中IL-18基因启动子区-607C/A位点存在多态性,但痛风与该多态性无相关性。
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| 关 键 词： | 痛风 白细胞介素18 多态性 单核苷酸 |
THE RELATIONSHIP BETWEEN THE MONONUCLEOTIDE POLYMORPHISM (SNP) AT POSITION-607 AT THE PROMOTER REGION OF INTERLEUKIN-18 GENE AND GOUT MORBIDITY |
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| WANG XIN-FENG,YUAN YING,LI CHANG-GUI,et al.THE RELATIONSHIP BETWEEN THE MONONUCLEOTIDE POLYMORPHISM (SNP) AT POSITION-607 AT THE PROMOTER REGION OF INTERLEUKIN-18 GENE AND GOUT MORBIDITY[J].Acta Academiae Medicinae Qingdao Universitatis,2010,46(3):196-198,202. |
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| Authors: | WANG XIN-FENG YUAN YING LI CHANG-GUI |
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| Institution: | WANG XIN-FENG,YUAN YING,LI CHANG-GUI,et al(Department of Endocrinology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
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| Abstract: | Objective To investigate the mononucleotide polymorphism(SNP) at position-607 at the promoter region of interleukin-18(IL-18) gene for the association with gout in Chinese Han population of Shandong province. Methods The polymorphism of promoter region in the IL-18 gene(607C/A) was studied in 100 gout patients and 100 non-gout controls by using sequence-specific primers polymerase chain reaction(PCR-SSP) and sequencing. Results The frequency of AA genotype in IL-18-607C/A was 0.18(18/100) in normal controls... |
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| Keywords: | gout interleukin-18 polymorphism single nucleotide |
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