| 溴莫普林的合成 |
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| 引用本文： | 林木荣,廖联安.溴莫普林的合成[J].中国新药杂志,2005,14(11):1318-1320. |
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| 作者姓名： | 林木荣 廖联安 |
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| 作者单位： | 1. 福建省永春制药厂,泉州,362600
2. 厦门大学化学系,厦门,361005 |
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| 摘 要： | 目的:合成溴莫普林.方法:以4-溴-3,5-二羟基苯甲酸一水化合物为起始原料,经甲基化-酯化、酰肼化、改进的McFadyeh-Stevens反应、Knoevenagel缩合,再与盐酸胍环合制备溴莫普林.结果:目标化合物经核磁共振氢谱、质谱、红外光谱等确证,溴莫普林的总收率为35.2%.结论:本方法条件温和,操作简单.
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| 关 键 词： | 澳莫普林 药物合成 4-澳-3 5-二羟基苯甲酸 抗菌药 |
| 文章编号： | 1003-3734（2005）11-1318-03 |
| 收稿时间： | 2005-06-08 |
| 修稿时间： | 2005-06-08 |
Synthesis of Brodimoprim |
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| LIN Mu-Rong,LIAO Lian-an.Synthesis of Brodimoprim[J].Chinese Journal of New Drugs,2005,14(11):1318-1320. |
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| Authors: | LIN Mu-Rong LIAO Lian-an |
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| Institution: | 1. Fujian Yongchun Pharmaceutical Factory, Quanzhou 362600, China; 2 Department of Chemistry, Xiamen University, Xiamen 361005, China |
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| Abstract: | Objective:To synthesize brodimoprim.Methods:Brodimoprim was synthesized from 4-bromo-3,5-dihydroxy benzoic acid via 5 chain reactions including methylation-esterification,hydrazination,modified Mcfadyen-Stevens reaction,Knoevenagel condensation and cyclization with guanidine hydrochloride.Results:The structure of target compound was verified by()~1H-NMR,MS and IR.The overall yield was 35.2%.Conclusion:The easily manipulated synthetic procedure is good for pilot manufacture. |
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| Keywords: | brodimoprim synthesis 4-bromo-3 5-dihydroxy benzoic acid antibacterial agent |
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