调脂药与叶酸、维生素B12对高脂血症和高同型半胱氨酸血症的疗效比较

为了探讨叶酸、维生素B12 治疗高同型半胱氨酸血症前后以及调脂药治疗高脂血症前后血脂和同型半胱氨酸的变化 ,应用舒降之及 /或力平脂治疗高脂血症 ,应用叶酸、维生素B12 治疗高同型半胱氨酸血症 ,并测定治疗前后同型半胱氨酸和血脂水平。结果发现 ,经调脂药治疗后 ,血脂下降显著 (P <0 .0 5 ) ,同型半胱氨酸下降不显著 (P >0 .0 5 ) ;应用叶酸、维生素B12 治疗后 ,同型半胱氨酸下降显著 (P <0 .0 0 1) ,血脂改变不显著。结果提示 ,调脂药降低血脂浓度 ,但对同型半胱氨酸作用不明显 ;叶酸、维生素B12 降低同型半胱氨酸水平 ,对血脂作用不明显

Changes of Plasma Homocystetine and Lipid before and after therapy

Aim To investigate the changes of plasma homocyst eine and lipid before and after therapy. Methods Simavatatin tablet s and/or Lipanthyl tablets were used to treat hyperlipidemic patients. Folate and Vitamin B 12 were used to tr eat hyperhomocysteinemia. Plasma homocysteine and lipid were detected before an d after treatment. Results After treatment of hyperl ipidemic patients, the decrease of lipid was significant but the decrease of hom ocysteine was not. After treatment of hyperhomocysteinemia, the decrea se of homocysteine was significant whilc the decrease of lipid was not. Conclusions With the treatment of hyperlipimia using Simava tatin tablets and Lipanthyl tablets, the plasma lipid decreased significant ly, but the plasma homocysteine decreased nonsignificantly. The plasma hom ocysteine decreased strongly by using Folate and Vitamin B 12 , but the chan ges of lipid were not significant.