|
|||||
|
|
The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis |
|
| Authors: | AM Havens Y Jung YX Sun J Wang RB Shah HJ Bühring KJ Pienta RS Taichman |
| Affiliation: | 1. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Ave, 48109-1078, Ann Arbor, Michigan, USA 5. Department of Ophthalmology, Affiliated hospital of Jiangsu University, 212001, Jiangsu, Zhenjiang, China 2. Department of Pathology, University of Michigan, 1500 E. Medical Center Drive, 48109-0692, Ann Arbor, Michigan, USA 3. Department of Internal Medicine II, Division for Hematology, Immunology, Oncology and Rheumatology, University Hospital, Tübingen, Germany 4. Department of Urology, University of Michigan, 1500 E. Medical Center Drive, 48109-0692, Ann Arbor, Michigan, USA |
| Abstract: | BackgroundThe chemokine stromal derived factor-1 (SDF-1 or CXCL12) and its receptor CXCR4 have been demonstrated to be crucial for the homing of stem cells and prostate cancers to the marrow. While screening prostate cancers for CXCL12-responsive adhesion molecules, we identified CD164 (MGC-24) as a potential regulator of homing. CD164 is known to function as a receptor that regulates stem cell localization to the bone marrow. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |