The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals |
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| Authors: | Lotte K Vogel Mona S?b? Camilla F Skjelbred Kathrine Abell Esben DK Pedersen Ulla Vogel Elin H Kure |
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| Affiliation: | (1) Department of Medical Biochemistry and Genetics, University of Copenhagen, Blegdamsvej 3, Denmark;(2) Telemark University College, Faculty of Arts and Sciences, B? i Telemark, Norway;(3) Department of Laboratory Medicine, Section of Medical Genetics, Telemark Hospital, Skien, Norway;(4) National Institute of Occupational Health, Copenhagen, Denmark;(5) Department of Pathology, Ullevaal University Hospital, Oslo, Norway |
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| Abstract: | Background It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase together changed the frequency of carcinoma formation to normal. This suggests that the ratio of matriptase to HAI-1 influences the malignant progression. The aim of this study has been to determine the ratio of matriptase to HAI-1 mRNA expression in affected and normal tissue from individuals with colorectal cancer adenomas and carcinomas as well as in healthy individuals, in order to determine at which stages a dysregulated ratio of matriptase/HAI-1 mRNA is present during carcinogenesis. |
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