2型糖尿病血管病变患者MMP9与Hcy相关性研究

目的：探讨2型糖尿病（T2DM）血管病变患者血清金属蛋白酶9（MMP9）水平、同型半胱氨酸（Hcy）水平、各自影响因素及二者间的关系。方法：测定66名2型糖尿病患者和20名健康人MMP9、Hcy及各相关临床生化指标,并对各因素进行相关分析。结果：2型糖尿病大血管病变组血清中MMP9和Hcy浓度显著高于单纯2型糖尿病组和正常组,但低于糖尿病肾病组。Hcy水平与年龄均正相关;MMP9与低密度脂蛋白（LDL）、胆固醇（CHO）、甘油三酯（TG）、血压和Hcy呈正相关,与高密度脂蛋白（HDL）呈负相关。结论：血清中的MMP9和Hcy浓度的检测对2型糖尿病血管病变的发生、发展有重要临床意义。

Relationship between Matrix metalloproteinase 9 and Homocysteine in vascular pathological changes of type 2 diabete patients

Objective：To explore the relationship between Matrix metalloproteinase 9 and Homocysteine in vascular pathological changes of type 2 diabete patients. Methods： The serum MMP9 and Hcy were determined in 66 patients with type 2 diabetes（including 20 cases of type 2 diabetes without complication,22 cases of type 2 diabetes macroangiopathy and 24 cases of diabetic nephropathy） and 20 healthy controls in which clinical and biochemical data were analysed. Results： MMP9 and Hcy concentration in type 2 diabetes with macroangiopathy group were high than that in serum of type 2 diabetes group and normal group, but were lower than that in diabetic nephropathy. Serum MMP9 was correlated positively with LDL、 CHO、TG、blood pressure、Hcy and correlated negatively with HDL . Conclusion： There is important clinical significance of detection of MMP9 in serum and Hcy concentration on vascular complications in occurrence and development of type 2 diabetes.