以声音嘶哑首发的Castleman病一例并文献复习

目的 探讨Castleman病(Castleman(s) disease,CD)的临床诊断及治疗现状,总结临床诊治经验.方法 回顾性分析我院1例以声音嘶哑为首发症状的胸内多中心型CD的临床资料.结果 本例因刺激性咳嗽、咳痰伴声音嘶哑入院,经手术病理检查确诊为透明血管型CD,临床分型为多中心型,术后予糖皮质激素对症治疗,随访1年未见复发.结论 CD的病因及发病机制尚未阐明,目前大量研究证实人类疱疹病毒-8感染和白细胞介素6可能是其主要致病因素,有效治疗措施还有待进一步研究.

Castleman(s) Disease First Manifesting Hoarseness: A case Report and Review of Literature

Objective To study the clinical diagnosis and treatment status of Castleman’s disease.Methods The process of diagnosis and treatment for one case with hoarseness as the first manifestation of multi-center type intrathoracic Castleman’s disease was analyzed according to relevant domestic and international literature.Then clinical experience was summarized.Results The patient suffered from the classified pathologic subtype of hyaline-vascular variant and with the multi-center type in clinic.There was no recurrence after surgery and after 1 year follow up following glucocorticoid treatments.Conclusion Although Castleman’s disease was found 50 years ago,its etiology and pathogenesis have not been elucidated,therefore,the scheme of symptomatic treatment and etiology treatment should be further studied.Current IL-6 and HHV-8 virus infection are possible factors of the disease.Research remains to be done before effective measures are worked out.