山豆根碱与山豆根苏林碱对血小板聚集和粘附的影响

观察山豆根碱（Ｄａｕ）及山豆根苏林碱（Ｄａｓ）对人血小板聚集和粘附功能的影响，并探讨其作用机制。结果表明，两者可抑制由二磷酸腺苷、花生四烯酸和胶原引起的血小板聚集，药物浓度与聚集抑制率表现出明显的量效关系。Ｄａｕ处理的血小板其对二磷酸腺苷、花生四烯酸和胶原诱导聚集抑制的ＩＣ５０（ｍｍｏｌ／Ｌ）分别为０．０４２（ｎ＝５），０．０２８（ｎ＝９）及０．０４６（ｎ＝１０）；Ｄａｓ则分别为０．０４２（ｎ＝５

Effects of Dauricine and Daurisoline on Platelet Aggregation and Adhesion

ur experiment showed that dauricine and daurisoline could inhibit platelet aggregation induced byseveral agonists in vitro.The IC_(50)of dauricine to platelet aggregation stimulated by ADP,AA and colla-gen was 0.042,0.028 and 0.045 mmol/L,and the IC_(50)of daurisoline to aggregation induced by themwas 0.042,0.026,and 0.057 mmol/L respectively.Daurisoline also expressed a strong inhibiting effecton platelet adhesion.The platelets treated with daurisoline had an increased cAMP level,which mightbe the reason for antiplatelet ability of daurisoline.