| 抗人结肠癌单克隆抗体在裸鼠移植瘤中的定位显像研究 |
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| 引用本文： | 李亚明,韩立波.抗人结肠癌单克隆抗体在裸鼠移植瘤中的定位显像研究[J].中国医科大学学报,1995,24(4):398-400. |
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| 作者姓名： | 李亚明 韩立波 |
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| 作者单位： | 第一临床学院核医学科，第一临床学院胸外科实验室，第二临床学院胸外科 |
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| 摘 要： | 采用２－巯基乙醇还原抗人结肠癌单抗ＣＭＵ１５行＾９９ｍＴｃ直接标记法标记，标记后ＣＭＵ１５免疫活性保持良好，标记率为９６％。载瘤裸鼠腹腔注入２４ｈ后，标记单抗在肿瘤内有较高的选择性浓聚，γ照相肿瘤清晰显示，对照组无选择性分布，提示＾９９ｍＴｃ－ＣＭＵ１５在肿瘤组织中有较好的特异性浓聚。
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| 关 键 词： | 结肠肿瘤 单克隆抗体 放射性核素 脏器照影 裸鼠 |
A Study of Radioimmunoimaging of Colon Cancer Using Monoclonal
Antibody Against Human Colon Cancer in Nude Mice |
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| Li Yaming,Han
Libe,Lu Jibin,et al.A Study of Radioimmunoimaging of Colon Cancer Using Monoclonal
Antibody Against Human Colon Cancer in Nude Mice[J].Journal of China Medical University,1995,24(4):398-400. |
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| Authors: | Li Yaming Han
Libe Lu Jibin |
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| Abstract: | mmunoactivity remained well after labeled with
method of 2-mercaptothanol reduction-mediatedand Tc-99m direct
labeling,having high labeling efficiencies(96%).24 hours later after
injection ofCMU 15 through I.P,there were higher selective
concentration of labeled monoclonal antibody in thetumor and clear
visulization of tumor ,indicating that Tc-99m CMU 15 can specifically
concentrate inthe tumor. |
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| Keywords: | colon tumor monoclonal antibody radionuclide imaging |
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