| 垂体后叶素对心肌单相动作电位的影响及机理 |
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| 引用本文： | 余微,冯志强,俞利萍,崔泽忠,喻式程. 垂体后叶素对心肌单相动作电位的影响及机理[J]. 四川生理科学杂志, 1998, 0(1) |
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| 作者姓名： | 余微 冯志强 俞利萍 崔泽忠 喻式程 |
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| 作者单位： | 华西医科大学生理教研室(余微)，泸州医学院生理教研室(冯志强，俞利萍，崔泽忠)，泸州医学院生理教研室(喻式程) |
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| 摘 要： | 用保持家兔处于闭胸状态记录心外膜心肌单相动作电位(MAP)的技术,研究垂体后叶素(Pt)对MAP的影响及机理。结果表明,Pt可致动物心率减慢、MAP振幅和V_(max)降低、MA时限延长和MAP间期不等以及室性早搏等。用阿托品(1mg/kg iv)或心得安、立其丁(各1mg/kg iv)或同时给予三种受体阻断剂后,再用Pt(2u/kg iv),出现与上述基本一致的电生理改变。结果提示:心肌MAP改变的机理是由于Pt直接作用于全身血管平滑肌使之收缩,外周阻力增加,心室的后负荷增大,心输出量减少和冠状动脉收缩血流阻力增加所致的全心性缺血。
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| 关 键 词： | 垂后叶素 心肌缺血 单相动作电位 家兔 |
Mechanism and Effects of Pituitrin on Myocardial Monophasic Action Potential |
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| Yu Wei,Feng Zhiqiang,Yu Liping,Cui Zezhong,Yu Shicheng. Mechanism and Effects of Pituitrin on Myocardial Monophasic Action Potential[J]. Sichuan Journal of Physiological Sciences, 1998, 0(1) |
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| Authors: | Yu Wei Feng Zhiqiang Yu Liping Cui Zezhong Yu Shicheng |
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| Abstract: | The mechanism and effect of pituitrin on monophasic action potential (MAP) were studied using the technique for recording MAP from epicardium in the closed-chest state in rabbits. The slow of the heart rate, decreased in MAP amplitude and Vmax, lengthening of MAP duration, interval irregularity and ventricular premature beats were observed after pituitrin. Basic idential elec-trophysiological changes from pituitrin as above were presented after atropine or propranolol or phen-tolamine or three blockers to etherly treated. It is suggest that the change in MAP is resulted from the myocardial ischemia for coronary vasoconstriction produced by pituitrin. |
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| Keywords: | monophasic action potential pituitrin myocardial ischemia rabbit |
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