| 藜芦心胺的合成 |
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| 引用本文： | 孔荣祖,方成林,华维一. 藜芦心胺的合成[J]. 中国药科大学学报, 1984, 0(2): 53-54 |
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| 作者姓名： | 孔荣祖 方成林 华维一 |
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| 作者单位： | 南京药学院有机化学教研室，南京药学院有机化学教研室，南京药学院有机化学教研室 |
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| 摘 要： | 藜芦心胺(Bevantolol)的化学名是1-(3,4-二甲氧苯乙氨基)-3-间甲苯氧基-2-丙醇盐酸盐。据文献报道,本品是对心脏有选择性的肾上腺素β-受体阻断剂。我们以3-甲氧基-4-羟基苯甲醛(Ⅰ)(香草醛)为起始原料先制得3,4-二甲氧基苯乙胺(Ⅸ),再以间甲基苯酚与3-氯代环氧丙烷反应制得1-氯-3-间甲苯氧基-2-丙醇(Ⅸ),然
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| 关 键 词： | 藜芦心胺 香草醛 肾上腺素β-受体阻断剂 |
SYNTHESIS OF LIROXINAN |
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| Kong Rongzu,Fang Chenglin and Hua Weiyi. SYNTHESIS OF LIROXINAN[J]. Journal of China Pharmaceutical University, 1984, 0(2): 53-54 |
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| Authors: | Kong Rongzu Fang Chenglin Hua Weiyi |
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| Affiliation: | Department of Organic Chemistry |
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| Abstract: | Liroxinan(Bevantolol),1-[(3,4-dimethoxy phenthyl)amino-]-3(m-tolyloxy)-2-propanol hydrochloride,an adrenergic beta receptor blocker,was prepared fromvanillin via two synthetic routes.One is 5-step reactions consisting of methylation,dismutation,chloration,cyanidation and catalytic hydrogenation with total yieldbeing about 52%,and the other is 3-step reactions consisting of methylation,condensation and reduction with total yield being about 66%. |
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| Keywords: | Liroxinan Vanillin Adrenergic beta receptor blocker |
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