| 荷移分光光度法测定阿奇霉素含量 |
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| 引用本文： | 李华侃, 张扬, 康剑锋. 荷移分光光度法测定阿奇霉素含量[J]. 中国现代应用药学, 2004, (6): 504-506. |
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| 作者姓名： | 李华侃 张扬 康剑锋 |
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| 作者单位： | 锦州医学院化学教研室,辽宁,锦州,121001 |
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| 摘 要： | 目的建立测定阿奇霉素(阿泽红霉素)制剂含量的方法.方法利用阿泽红霉素与茜素红在水-醇介质中发生电荷转移反应,形成电荷转移络合物,采用可见分光光度法测定.结果荷移反应生成的荷移络合物在525nm处有最大吸收,表观摩尔吸光系数是1.26×104L/(mol·cm),药物浓度在5～55mg/L内服从比耳定律,方法平均回收率在97.0%以上,RSD为0.95%(n=6).结论方法稳定、准确、灵敏、快速,对样品的测定结果令人满意.
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| 关 键 词： | 电荷转移反应 茜素红 阿奇霉素 分光光度法 |
| 文章编号： | 1007-7693(2004)06-0505-02 |
Spectrophotometric determination of azithromycin based on the charge transfer reaction between azithromycin and alizarin red |
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| LI Hua-kan, ZHANG Yang, KANG Jian-feng. Spectrophotometric determination of azithromycin based on the charge transfer reaction between azithromycin and alizarin red[J]. Chinese Journal of Modern Applied Pharmacy, 2004, (6): 504-506. |
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| Authors: | LI Hua-kan ZHANG Yang KANG Jian-feng |
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| Abstract: | OBJECTIVE To establish a method for rapid determination of azithromycin.METHOD To utilize visible spectrophotometry based on the charge transfer reaction between azithromycin as donor and alizarin red as acceptor in alcohol-water solution. RESULTS The app |
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| Keywords: | charge transfer reaction alizarin red azithromycin spectrophotometry |
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