| 异种移植组织相容性及免疫动态变化测试模型 |
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| 引用本文： | 张海涛,李幼平.异种移植组织相容性及免疫动态变化测试模型[J].中国修复重建外科杂志,2002,16(3):205-208. |
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| 作者姓名： | 张海涛 李幼平 |
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| 作者单位： | 四川大学华西医院移植工程和移植免疫实验室,成都,610041 |
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| 基金项目： | 国家自然科学基金资助项目 (39770 766) |
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| 摘 要： | 目的 综述异种移植物抗宿主反应 (GVHD)动物模型的研究现状、检测方法及进展情况。方法 采用文献回顾与综合分析方法。结果 免疫活性细胞植入异种受者体内后 ,有发生排斥 (HVGD)、移植物抗宿主反应(GVHD)和微嵌合的可能 ,异种 GVHD已在小动物和大动物体内成功诱导 ,并可通过多种途径进行检测。结论 异种GVHD大动物模型 ,主导因素是嵌合细胞 ,利用该模型可真实模拟异种移植免疫细胞动态变化过程
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| 关 键 词： | 异种移植 移植物抗宿主反应 动物模型 |
| 修稿时间： | 2001年12月31 |
ANIMAL MODEL OF IMMUNOLOGIC CHANGE DETECTION IN VIVO AFTER XENOTRANSPLANTATION |
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| ZHANG Hai tao,LI You ping. Laboratory of Transplant Engineering and Transplant Immunology,West China Hospital,Sichuan University. Chengdu Sichuan,P. R. China.ANIMAL MODEL OF IMMUNOLOGIC CHANGE DETECTION IN VIVO AFTER XENOTRANSPLANTATION[J].Chinese Journal of Reparative and Reconstructive Surgery,2002,16(3):205-208. |
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| Authors: | ZHANG Hai tao LI You ping Laboratory of Transplant Engineering and Transplant Immunology West China Hospital Sichuan University Chengdu Sichuan P R China |
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| Institution: | Laboratory of Transplant Engineering and Transplant Immunology, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China 610041. |
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| Abstract: | Objective To review the current condition, test method and progress of the animal model of xeno graft versus host disease(xeno GVHD). Methods The literature review and comprehensive analysis methods were used in this article. Results Implanted immunologic cells, the recepient had the chance of showing host versus graft reaction, GVHD or microchimerism. Now, xeno GVHD could be induced in vivo at small and large animals, it also could be supervised through many ways. Conclusion Chimeric cells is very important to xeno GVHD animal model. With this model, we can really mimic the immunologic change in vivo after xenotransplantation. |
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| Keywords: | Xenotransplantation Graft versus host disease Animal model |
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