| 阴道黏膜给药系统的研究进展 |
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| 引用本文： | 马冬冬,孟庆丽,刘红梅,吴琳华,唐景玲. 阴道黏膜给药系统的研究进展[J]. 中国药师, 2015, 0(4): 649-697 |
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| 作者姓名： | 马冬冬 孟庆丽 刘红梅 吴琳华 唐景玲 |
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| 作者单位： | 哈尔滨医科大学药学院;哈尔滨医科大学附属第二医院药学部 |
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| 基金项目： | 黑龙江省应用技术研究与开发计划项目(编号:GC13C113) |
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| 摘 要： | 目的:综述阴道黏膜给药系统的最新应用进展。方法:根据国内外发表的文献,对阴道黏膜给药系统的应用加以分析和讨论。结果:阴道黏膜给药安全、有效、能避免首关效应、渗透性能强,延长药物滞留时间,提高生物利用度,可以改善患者用药顺应性。结论:阴道黏膜给药系统已成为目前研究的热点,它是传统给药方式的补充,具有广阔的应用前景。
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| 关 键 词： | 阴道黏膜给药 凝胶 阴道膜剂 脂质体 纳米银 |
| 收稿时间： | 2014-09-04 |
| 修稿时间： | 2014-11-19 |
Study Progress in Vaginal Mucoadhesive Drug Delivery Systems |
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| Ma Dongdong,Meng Qingli,Liu Hongmei,Wu Linhua and Tang Jingling. Study Progress in Vaginal Mucoadhesive Drug Delivery Systems[J]. China Pharmacist, 2015, 0(4): 649-697 |
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| Authors: | Ma Dongdong Meng Qingli Liu Hongmei Wu Linhua Tang Jingling |
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| Affiliation: | Ma Dongdong;Meng Qingli;Liu Hongmei;Wu Linhua;Tang Jingling;College of Pharmacy,Harbin Medical University;Department of Pharmacy,the Second Affiliated Hospital of Harbin Medical University; |
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| Abstract: | ABSTRACT Objective: To review the progress in vaginal mucoadhesive drug delivery systems. Methods: Based on the recently published papers, the research on the application of vaginal mucoadhesive drug delivery systems was classified and summarized.Results: Vaginal mucoadhesive drug delivery systems not only showed safety, effectiveness and strong permeability but also avoided the first pass effect, prolonged drug residence time and improved bioavailability and compliance of patients. Conclusion:Vaginal mucoadhesive drug delivery systems are becoming research hotspots and exhibit broad application prospects to replace the traditional delivery systems. |
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| Keywords: | Vaginal mucoadhesive drug delivery Gels Vaginal films Liposomes Nano silver |
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