| 埃博拉病毒病疫苗研究进展 |
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| 引用本文： | 金宏丽,王化磊,郑学星,杨松涛,夏咸柱.埃博拉病毒病疫苗研究进展[J].传染病信息,2015,28(2):70-74. |
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| 作者姓名： | 金宏丽 王化磊 郑学星 杨松涛 夏咸柱 |
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| 作者单位： | 1. 130122 长春,军事医学科学院军事兽医研究所病毒学研究室 吉林省人兽共患病预防与控制重点实验室;130122 长春西诺生物科技有限公司;2. 军事医学科学院军事兽医研究所病毒学研究室 吉林省人兽共患病预防与控制重点实验室, 长春,130122 |
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| 基金项目： | 国家"十二五"科技重大专项 |
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| 摘 要： | 埃博拉病毒病(Ebola virus disease, EVD)是由埃博拉病毒引起的一种急性出血性传染病. 自2014年3月以来, EVD在西非多个国家暴发,引起全球关注,WHO已将此疫情列为国际关注的突发公共卫生事件.虽然有很多因素限制了EVD疫苗的发展,目前无可用于人的疫苗获批上市,但当前的严峻形式促进了疫苗研究的发展. 本文着重介绍EVD疫苗相关的研究进展,包括评价疫苗所用的动物模型、疫苗种类和进入临床试验的疫苗.
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| 关 键 词： | 埃博拉病毒属 埃博拉疫苗 模型 动物 |
Advances in the development of Ebloa vaccines |
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| JIN Hong-li,WANG Hua-lei,ZHENG Xue-xing,YANG Song-tao,XIA Xian-zhu.Advances in the development of Ebloa vaccines[J].Infectious Disease Information,2015,28(2):70-74. |
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| Authors: | JIN Hong-li WANG Hua-lei ZHENG Xue-xing YANG Song-tao XIA Xian-zhu |
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| Institution: | JIN Hong-li;WANG Hua-lei;ZHENG Xue-xing;YANG Song-tao;XIA Xian-zhu;Laboratory of Virology, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences,Key Laboratory of Jilin Province for Zoonosis Prevention and Control; |
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| Abstract: | Ebola virus disease (EVD), caused by Ebola virus (EBOV), is a severe hemorrhagic contagious disease. Since March 2014, it has spread in several countries of West Africa, which have captivated the world's attention and concern, and WHO declared the EVD outbreak in West Africa as a public health emergency of international concern. Though several impeding factors have limited the development of Ebola vaccines and there are no approved Ebola vaccines for humans, the current epidemic has provided a surge for faster development of Ebola vaccines. This article focuses on the advances in the development of Ebola vaccines, including animal mo-dels for vaccine evaluation, types of Ebola vaccines and clinical studies of experimental vaccines. |
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| Keywords: | Ebolavirus Ebola vaccines models animal |
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