润洁萘扑维滴眼液治疗视疲劳的初步临床观察

目的 :评价润洁萘扑维滴眼液治疗视疲劳的临床效果。方法 :应用润洁萘扑维滴眼液治疗 4 2例视疲劳者 ,分别于用药前、用药后 1d、用药后 3d、用药后 7d、用药后 1 4d评估患者的症状和体征 ,同时观察药物的不良反应 ,进行评分。结果 :与用药前相比 ,总积分 (P <0 .0 0 0 )、异物感 (P =0 .0 0 3)、烧灼感 (P =0 .0 0 4 )、眼痛 (P =0 .0 0 6 )、流泪 (P =0 .0 1 4 )、充血 (P =0 .0 1 )等指标的积分于用药后 1d下降 ,差异有显著性。畏光 (P =0 .0 0 1 )、睑痉挛 (P =0 .0 2 6 )、头晕头痛(P =0 .0 0 5)积分于用药后 3d下降 ,差异有显著性。除头晕头痛指标积分有反弹外 (用药后 7d和 1 4d ,P >0 .0 5) ,其余指标的积分均随着时间延长而逐渐下降。恶心呕吐症状在用药观察期间无明显改变。有 8例发生一过性眼局部不良反应 ,其中 1例伴有轻微的头痛。结论 :润洁萘扑维滴眼液1 4d内能安全有效地缓解视疲劳的一些症状和体征。

A primary clinical assessment of renown eye drops on asthenopia

Objective:To evaluate the effects of renown eye drops on asthenopia.Methods:Forty two subjects (84 eyes) with asthenopia were included in this 14 day study. Each eye was treated with renown eye drops. Symptoms and signs were scored according to defined criteria before and one day,3 days,7 days and 14 days after the instillation of renown eye drops. Side effects,if any,were noted during the study.Results:Pan score,scores of foreign body sensation,burning sensation,ophthalmalgia,tearing and hyperemia changed significantly from before to one day after the instillation of renown eye drops. Scores for symptoms of photophobia,blepharospasm and headache were significantly reduced after three days,however,no statistical difference was found in headache seven days after treatment. Eight cases showed transient local side effects in using the eye drops,one of which was associated with a slight headache.Conclusion:Renown eye drops can ameliorate the symptoms and signs of asthenopia safely and effectively.