诱骗受体3在类风湿关节炎病人血清中的表达水平及其临床意义

目的:探讨血清诱骗受体3(DcR3)在类风湿关节炎(RA)病人血清中的表达水平及其临床意义.方法:选取RA病人60例(RA组),并按照疾病活动指数≤2.6分或>2.6分将病人为RA低活动组和RA活动组;同期选取健康体检者30名作为对照组.采用ELISA法测定各组血清DcR3和γ-干扰素(IFN-γ)水平.结果:RA组病人血清DcR3、IFN-γ水平均明显高于对照组(P<0.01).RA活动组、低活动组和对照组血清DcR3、IFN-γ水平间差异均有统计学意义(P<0.01),其中RA活动组血清DcR3、IFN-γ水平均明显高于RA低活动组和对照组(P<0.01),RA低活动组IFN-γ水平亦明显高于对照组(P<0.01).RA病人血清DcR3与IFN-γ水平呈正相关关系(P<0.05).结论:DcR3在RA病人血清中表达增高,且与IFN-γ水平呈正相关关系,其可能参与RA的发病过程,与RA病情活动度有一定联系,可辅助判断RA的病情活动度.

The expression and clinical significance of serum decoy receptor 3 in patients with rheumatoid arthritis

Objective:To investigate the expression level of serum decoy receptor 3(DcR3) in patients with rheumatoid arthritis (RA),and its clinical significance.Methods:Sixty RA patients and 30 healthy donators were divided into the RA group and control group,respectively,and the RA group were subdivided into the low activity group and activity group according to the disease activity index.The serum levels of DcR3 and IFN-γ in two groups were detected using enzyme-linked immunosorbent assay(ELISA).Results:The levels of DcR3 and IFN-γ in RA group were significantly higher than those in control group(P<0.01).The differences of the serum levels of DcR3 and IFN-γ between activity group,low activity group and control group were statistically significant(P<0.01). The serum levels of DcR3 and IFN-γ in activity group were significantly higher than those in activity group and control group(P<0.01).The serum level IFN-γ in low activity group was significantly higher than that in control group(P<0.01).The serum level of DcR3 in RA patients was positive correlation with the level of IFN-γ(P<0.05).Conclusions:The expression levels of DcR3 and IFN-γ increase in RA patients,and which is positive correlation with the level of IFN-γ.DcR3 may be involved in the pathogenesis of RA, and is related to the disease activity.