甲状腺乳头状癌合并桥本甲状腺炎的临床和病理特点分析

目的:总结甲状腺乳头状癌(PTC)合并桥本甲状腺炎(HT)的临床及病理特点.方法:收集43例PTC合并HT病人(观察组),并选取同期仅诊断为PTC病人45例(对照组),比较2组病人的临床及病理特点.结果:观察组病人出现甲状腺肿大以及颈部压迫症状较对照组病人明显增多(P<0.01);2组病人甲状腺肿块、颈部疼痛、声音嘶哑、吞咽困难等症状差异均无统计学意义(P>0.05);观察组女性、年龄≤44岁病人所占比例均高于对照组(P<0.05);2组病人淋巴结转移、临床分期、癌肿类型、癌灶数、预后等差异均有统计学意义(P<0.05~P<0.01).结论:与单纯PTC相比,PTC合并HT以颈部肿大或颈部压迫症状较多见,中青年及女性病人发病率高,淋巴结转移少,临床分期早,预后较好.

Clinical and pathological characteristics of papillary thyroid carcinoma complicated with hashimoto thyroiditis

Objective:To investigate the clinical and pathological characteristics of papillary thyroid carcinoma(PTC) complicated with hashimoto thyroiditis(HT).Methods:Forty-three patients with PTC complicated with HT and 45 patients with PTC were divided into the observation and control group,respectively.The clinical and pathological characteristics between two groups were compared.Results:The thyroid enlargement and neck compression symptoms in observation group were more than those in control group(P<0.05).The differences of the goiter,neck pain,hoarseness and swallowing difficulty between two groups were not statistically significant(P>0.05).The proportion of female and less than or equal to 44 years old patients in observation group were significantly higher than those in control group(P<0.05).The differences of lymph node metastasis,clinical stage,tumor type,number of cancer lesion and prognosis between two groups were statistically significant(P<0.05).Conclusions:Compared with the PTC patients,the thyroid enlargement and neck compression symptom in PTC complicated with HT patients are more common.The young middle-aged people female,less lymph node metastasis,earlier clinical stage and better prognosis are the main clinical characteristics.