宫颈癌盆腔淋巴结转移的临床特征及影响因素分析

目的 分析宫颈癌盆腔淋巴结转移的临床特征,探究影响宫颈癌患者盆腔淋巴结转移的危险因素,为改善患者预后和提高生活质量提供一定的科学依据.方法 收集300例宫颈癌患者的一般人口学特征和临床分期、分化程度、肿瘤直径、组织学类型、肿瘤浸润深度、脉管癌栓情况、肿瘤宫旁浸润情况及患者术前化疗情况等资料.采用Logistic进行影响因素分析.结果 300例宫颈癌患者,35例发生淋巴结转移,占11.7％.临床分期为Ⅱ期的患者发生盆腔淋巴结转移的风险是Ⅰ期的3.283倍;肿瘤直径≥4 cm的患者发生淋巴结转移的风险是﹤4 cm的2.332倍;浸润深度≥1/2的患者发生淋巴结转移的风险是﹤1/2的1.823倍;脉管癌栓阳性的患者发生淋巴结转移的风险是阴性患者的1.739倍;宫旁浸润阳性的患者发生淋巴结转移的风险是阴性患者的1.672倍.结论肿瘤直径、临床分期、肿瘤浸润深度、宫旁浸润和脉管癌栓与宫颈癌盆腔淋巴结转移有关.

Clinical characteristics and factors influencing the pelvic lymph node metastasis in cervical cancer

Objective To explore the clinical characteristics of pelvic lymph node metastasis in cervical cancer pa-tients, and to investigate the risk factors to justify appropriate measures for improving the prognosis and quality of life of patients. Method A total of 300 patients with cervical cancer were included in the study. The information covering gen-eral demographic characteristics and clinical stage, differentiation, tumor diameter, histological type, depth of tumor inva-sion, vascular tumor thrombus, tumor infiltration and preoperative chemotherapy were collected. Logistic analysis was used to analyze the risk factors. Result Of the 300 cancer patients, 35 (11.7％) had lymph node metastasis. The risk of lymph node metastasis in patients with stage II disease was found to be 3.283 times higher than that of those with stage I disease;and patients with tumor diameter≥4 cm had 2.332 times increased risk of lymph node metastases compared to those with tumor diameter<4 cm;the infiltration depth of≥1/2 was associated with 1.823 times greater risk compared to infiltration depth <1/2; positive vascular tumor thrombus and positive uterine infiltrations were associated with 1.739 times and 1.672 times increased risk of lymph node metastasis, respectively. Conclusion Tumor diameter, clinical stage, depth of tumor invasion, uterine infiltration and vascular tumor thrombus are associated with cervical lymph node metas-tasis in cervical cancer.