CIP2A、IGF-2、PCNA、NGF及c-Myc在老年胶质瘤中的表达及其与预后的关系

目的 探讨CIP2A、IGF-2、PCNA、NGF及c-Myc在老年胶质瘤中的表达及其与预后的关系.方法检测CIP2A、IGF-2、PCNA、NGF及c-Myc在老年胶质瘤中的表达情况,对其进行多因素分析,探讨与老年胶质瘤的关系.结果CIP2A在Ⅰ～Ⅱ级老年胶质瘤组织中阳性表达率为50.00％,在Ⅲ～Ⅳ级中阳性表达率为77.78％,而对照组为12.50％;c-Myc在Ⅰ～Ⅱ级胶质瘤组织中阳性表达率为45.45％,在Ⅲ～Ⅳ级中阳性表达率为72.22％,而对照组为17.50％;NGF在Ⅰ～Ⅱ级老年胶质瘤中阳性表达率为40.91％,在Ⅲ～Ⅳ级中阳性表达率为83.33％,而在对照组中无表达;IGF-2在Ⅰ～Ⅱ级和Ⅲ～Ⅳ级胶质瘤组织中阳性表达率均为100.00％,而在对照组中无表达;PC-NA主要表达于胶质瘤细胞的细胞核之中,在Ⅰ～Ⅱ级胶质瘤组织中阳性表达率为45.45％,在Ⅲ～Ⅳ级为83.33％,而在对照组中无表达.观察组CIP2A、IGF-2、PCNA、NGF及c-Myc阳性表达率均高于对照组(P﹤0.05).在观察组中,Ⅲ～Ⅳ级胶质瘤中CIP2A、PCNA、NGF及c-Myc阳性表达率均高于Ⅰ～Ⅱ级胶质瘤阳性表达率(P﹤0.05).Logistic多元回归分析结果显示,CIP2A、IGF-2、PCNA、NGF与c-Myc是影响老年胶质瘤表达的独立因素.结论CIP2A、IGF-2、PCNA、NGF及c-Myc在老年胶质瘤中的表达与胶质瘤恶性程度有关,均可作为诊断老年胶质瘤的重要指标,为预测预后、判断胶质瘤生物学行为提供依据.

The expression and correlation between CIP2A,IGF-2, PCNA,NGF and c-Myc in elderly patients with glioma

Objective To study the expression and correlation between CIP2A, IGF-2, PCNA and NGF and c-Myc in elderly patients with glioma. Method The expression of CIP2A, IGF-2, PCNA and NGF and c-Myc in elderly patients with glioma were detected, and the multivariate analysis was carried out to determine the correlation between these index-es and the glioma in elderly patients. Result The positive expression rate of CIP2A in elderly patients with glioma at grade I-II was 50.00％, and was 77.78％in grade III-IV disease, while that in the control group was 12.50％;the positive expression rate of c-Myc in patients with glioma at grade I-II was 45.45％, and was 72.22％in those with grade III-IV dis-ease, while that in the control group was 17.50％;for NGF, the data were 40.91％and 83.33％in I-II and III-IV group, and there was no expression in the control group;IGF-2 had 100.00％of positive expression rate in the grade I-II and III-IV glioma tissues, and there was no expression in the control group; PCNA mainly expressed in the nucleus of glioma cells, and the positive expression rate in grade I～II and III～IV glioma tissues was 45.45％and 83.33％, respectively, simi-larly, no expression was observed in the control group. The positive expression rate of CIP2A, IGF-2, PCNA, NGF and c-Myc were all significantly higher in study group than control group (P<0.05). By Logistic multivariate regression analy-sis, it was found that, CIP2A, IGF-2, PCNA, NGF and c-Myc were independent factors influencing the expression of el-derly patients with gliomas. Conclusion The expression of CIP2A, IGF-2, PCNA, NGF and c-Myc in elderly patients with glioma is correlated with the severity of glioma, besides, may be used as important indexes for the diagnosis of elder-ly patients with glioma, which helps to predict the prognosis and determine the biological behavior of glioma.