子宫内膜样腺癌血管内皮生长因子的表达情况及临床意义

目的 探讨子宫内膜样腺癌血管内皮生长因子(VEGF)的表达情况及临床意义.方法 采用免疫组织化学方法检测49例子宫内膜样腺癌、10例不典型增生子宫内膜及10例正常子宫内膜标本中的VEGF表达情况,同时检测子宫内膜样腺癌组织中雌激素受体(ER)及孕激素受体(PR)的表达情况,分析VEGF阳性表达率与各临床病理参数的关系.结果 子宫内膜样腺癌组织、不典型增生子宫内膜组织和正常子宫内膜组织的VEGF阳性表达率比较,差异有统计学意义(P﹤0.05);子宫内膜样腺癌组织的VEGF阳性表达率高于正常子宫内膜组织(P﹤0.05).病理分级和临床病理分期是子宫内膜样腺癌组织VEGF阳性表达的独立因素(P﹤0.05).结论VEGF在子宫内膜的恶性转变和细胞分化中发挥重要作用,在判断子宫内膜样腺癌的恶性程度和患者预后评价方面具有一定的价值.

Expression and clinical significance of vascular endothelial growth factor in endometrioid adenocarcinoma

Objective To investigate the expression and clinical significance of vascular endothelial growth factor (VEGF)in endometrioid adenocarcinoma(EA).Method The expression levels of VEGF were detected by immunohisto-chemistry in 49 cases of EA,10 cases of atypical hyperplasia of endometrium and 10 cases of normal endometrium,and the expression of ER and PR were detected in tissues of EA,then the relationships among expression levels of VEGF in EA and the clinicopathological parameters were analyzed.Result The positive expression rates of VEGF in EA,normal endometrium,and atypical hyperplasia of endometrium were of significant differences(P<0.05);higher positive expres-sion rate of VEGF was observed in EA tissues compared to normal endometrium(P<0.05).The pathological grading and clinicopathological stage were independent factors of positive expressions of VEGF (P<0.05). Conclusion The study suggests that VEGF plays an important role in malignant transformation and cell differentiation of endometrium. And VEGF is somewhat useful in determining the malignant grade of EA and patients'prognosis.