血尿酸水平与2型糖尿病患者下肢动脉病变的相关性研究

目的:探讨血尿酸(SUA)水平与2型糖尿病(T2DM)患者下肢动脉血管病变(LEAD)的相关性.方法:431例T2DM患者,根据SUA四分位数分为4组:Q1组,≤252μmol/L,108例;Q2组,253~323μmol/L,108例;Q3组,324~430μmol/L,107例;Q4组,≥431μmol/L,108例.采用动脉硬化检查装置/血压脉波检查装置测定踝肱指数(ABI).记录一般资料,检测生化指标,研究SUA水平与T2DM患者LEAD的相关性.结果:Q1组与Q2组间LEAD发生率差异无统计学意义(P>0.05);与Q1组比较,Q3组、Q4组LEAD发生率均显著升高(P<0.01).logistic回归分析显示,Q3组(OR:3.44,95%CI:1.90~6.20,P<0.01)、Q4组(OR:8.31,95%CI:4.50~15.35,P<0.01)LEAD发生率显著升高.结论:随着SUA水平升高,T2DM患者LEAD发生率增加;高SUA水平是T2DM患者LEAD的危险因素.

The correlation study between the serum uric acid level and lower extremity arterial disease in patients with type 2 diabetes mellitus

Objective:To explore the correlation between the serum uric acid ( SUA ) level and lower extremity arterial disease (LEAD) in patients with type 2 diabetes(T2DM)mellitus. Methods:Four hundred and thirty-one patients with T2DM were divided into Q1 group(108 cases,SUA≤252 μmol/L),Q2 group(108 cases,SUA>252-323 μmol/L),Q3 group(107 cases,SUA >324-430μmol/L) and Q4 group(108 cases,SUA>430μmo/L) according to the quartile of serum uric acid. The ankle brachial index(ABI) of all patients was determined using the arteriosclerosis/blood pressure pulse check device. The general data and biochemical index were recorded. The correlation between the SUA level and LEDA in patients with T2DM was investigated. Results:The difference of the LEAD incidence between Q1 group and Q2 group was not statistically significant(P>0. 05). Compared with the Q1 group,the LEAD incidence in Q3 and Q4 groups significantly increased(P<0. 01). The logistic regression analysis showed that the LEAD incidence in Q3 group(OR:3.44,95%CI:1. 90 -6. 20,P <0. 01) and Q4 group(OR:8. 31,95%CI:4. 50 ~15. 35,P <0. 01) significantly increased. Conclusions:With the increasing of the SUA level,the incidence of LEDA in T2DM patients increases. The high SUA level is a risk factor of LEAD in T2DM patients.