活性纳米碳对行甲状腺全切术甲状腺肿瘤病人甲状旁腺保护作用

目的:研究活性纳米碳对行甲状腺全切术甲状腺肿瘤病人甲状旁腺保护作用.方法:选择甲状腺癌病人102例,随机选择52例术中先注射纳米碳混悬液于甲状腺内,后行甲状腺全切除术(观察组),另外50例仅做常规甲状腺全切除术(对照组),术后3 d检测病人血清甲状旁腺激素(PTH)和血钙水平,并比较2组正常、低PTH以及低血钙的发生率.结果:观察组在切除的组织标本中有甲状旁腺病人少于对照组(P<0.05),手术后暂时性甲状旁腺功能减低病人亦少于对照组(P<0.05),暂时性甲状旁腺功能减低的恢复时间明显短于对照组(P<0.01).观察组术后24 h血清PTH和血钙降低率均低于对照组(P<0.05).观察组病人治疗后血清PTH平均水平、血钙正常的病人血清PTH水平以及血钙降低的病人血清PTH水平均明显高于对照组(P<0.01).观察组治疗后血钙平均水平和血清PTH降低病人的血钙水平亦均明显高于对照组(P<0.01).结论:甲状腺肿瘤病人行甲状腺全切除术中应用活性纳米碳可对甲状旁腺起到一定的保护作用.

Protective effect of the activated nanocarbon on parathyroid in thyroid tumor patients treated with total thyroidectomy

Objective:To investigate the protective effects of the activated nanocarbon on parathyroid in thyroid tumor patients treated with total thyroidectomy. Methods:One hundred and two thyroid tumor patients were randomly divided into the observation group(52 cases) and control group(50 cases). The thyroid in observation group were firstly injected with nanocarbon suspension,and then the patients were treated with total thyroidectomy. The control group were treated with total thyroidectomy. The levels of serum parathyroid hormone( PTH) and calcium in two groups were detected after 3 days of surgery. The number of patients with normal,low PTH and low calcium between two groups were compared. Results:The number of patients with parathyroid disease in observation group was less than that in control group(P<0. 05),the number of patients with temporary hypoparathyroidism after surgery in observation group was less than that in control group (P<0. 05),and the recovery time of the temporary hypoparathyroidism in observation group was significantly less than that in control group(P<0. 01). The decreasing rates of the levels of serum PTH and calcium in observation group after two hours of operation were lower than those in control group(P<0. 05). After treatment,the average level of serum PTH,and the serum PTH level in patients with normal calcium and serum calcium decreasing in observation group were significantly higher than those in control group(P<0. 01). After treatment,the average level of serum calcium,and the serum calcium level in patients with serum PTH decreasing in observation group were significantly higher than those in control group(P <0. 01). Conclusions:The application of activated nanocarbon in thyroid tumor patients treated with total thyroidectomy can play a protective effect on parathyroid.