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CYP4F2基因多态性与云南汉族人群冠心病的相关性研究
引用本文:王晓焕,张云坤,傅薇,曹鸿鹍. CYP4F2基因多态性与云南汉族人群冠心病的相关性研究[J]. 蚌埠医学院学报, 2017, 42(5). DOI: 10.13898/j.cnki.issn.1000-2200.2017.05.002
作者姓名:王晓焕  张云坤  傅薇  曹鸿鹍
作者单位:云南省第二人民医院 老年病科,云南 昆明,650021;云南省第二人民医院 老年病科,云南 昆明,650021;云南省第二人民医院 老年病科,云南 昆明,650021;云南省第二人民医院 老年病科,云南 昆明,650021
摘    要:目的:研究CYP4F2基因多态性与中国云南汉族人群冠心病(CHD)的相关性.方法:采用Sequenom MassARRAY 对云南汉族人群198名正常人(对照组)和514例CHD病人(CHD组)CYP4F2基因rs2108622、rs3093135两个单核苷酸多肽位点的多态性进行基因分型,分析该基因多态性与CHD的相关性.结果:对照组和CHD组两个等位基因频率分布差异有统计学意义(P<0.01);校正年龄、性别、体质量指数等因素后logistic回归分析显示rs2108622位点携带T等位基因者患CHD的风险降低(P<0.05);rs3093135位点携带A等位基因者患CHD风险降低(P<0.05).结论:CYP4F2基因多态性与云南汉族人群CHD发生风险相关.

关 键 词:冠状动脉疾病  基因多态  CYP4F2

Study of the correlation between the gene polymorphism of CYP24F2 and coronary heart disease in Yunnan Han population
WANG Xiao-huan,ZHANG Yun-kun,FU Wei,CAO Hong-kun. Study of the correlation between the gene polymorphism of CYP24F2 and coronary heart disease in Yunnan Han population[J]. Journal of Bengbu Medical College, 2017, 42(5). DOI: 10.13898/j.cnki.issn.1000-2200.2017.05.002
Authors:WANG Xiao-huan  ZHANG Yun-kun  FU Wei  CAO Hong-kun
Abstract:Objective:To investigate the correlation between the gene polymorphism of CYP4F2 and coronary heart disease(CHD) in Yunnan Han population.Methods:The polymorphisms of rs2108622 and rs3093135 single nucleotide polymorphism(SNP) in CYP4F2 gene of 198 normal people(control group) and 514 patients with CHD(CHD group) were genotyped using the SEQUENOM Mass-ARRAY system.The correlation between the gene polymorphism of CYP4F2 and CHD was analyzed.Results:The difference of two allele frequencies between two group was statistically significant(P<0.01).After adjusting the age,gender and body mass index,the logistic regression analysis showed that the CHD risk of patients with rs2108622 T allele decreased(P<0.05),and the CHD risk of patients with rs3093135 A allele decreased(P<0.05).Conclusions:The gene polymorphism of CYP4F2 is correlated with the risk of the CHD in Yunnan Han population.
Keywords:coronary heart disease  gene polymorphism  CYP4F2
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