单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的疗效观察

目的:评估单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹的临床疗效,探讨带状疱疹后遗神经痛(PHN)发生的影响因素.方法:183例急性带状疱疹病人随机分为观察组(单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗,77例)和对照组(单磷酸阿糖腺苷联合窄谱中波紫外线治疗,106例).对2组疱疹指标、疼痛视觉模拟评分、综合疗效及PHN的发生率进行分析.结果:观察组病人止疱时间、结痂时间和脱痂时间均明显短于对照组(P<0.01);治疗10 d后观察组疼痛视觉模拟评分低于对照组(P<0.01);观察组治疗总有效率高于对照组(P<0.05),观察组1个月及3个月PHN的发生率均低于对照组(P<0.05).多因素logistic回归分析显示,年龄、治疗前疼痛视觉模拟评分及是否为对照组均为PHN发生的独立危险因素(P<0.05~P<0.01).结论:单磷酸阿糖腺苷联合窄谱中波紫外线及LED光动力治疗带状疱疹疗效显著,并且可以预防PHN的发生.

Effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster

Objective:To evaluate the clinical efficacy of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster,and investigate the influencing factors of postherpetic neuralgia(PHN).Methods:One hundred and eighty-two patients with acute herpes zoster were randomly divided into the observation group(77 cases treated with vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics) and control group(106 cases treated with vidarabine monophosphate combined with narrow-band ultraviolet).The indicators of herpes,visual analogue scale(VAS) score,comprehensive curative effects and incidence rates of postherpetic neuralgia between two groups were analyzed.Results:The times of response,scab form and decrustation in observation group were significantly shorter than those in control group(P<0.01).The VAS score after 10 days of treatment in observation group was lower than that in control group(P<0.01).The total effective rate in observation group was higher than that in control group(P<0.05),and the incidence rates of PHN at 1 month or 3 months of treatment in observation group were lower than that in control group(P<0.05).Multivariate logistic regression analysis showed that the age and VAS score before treatment were the independent risk factor of PHN(P<0.05 to P<0.01).Conclusions:The effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster is significant,which can prevent the incidence of PHN.