乳腺原发性印戒细胞癌与乳腺黏液腺癌分子指标及预后的比较

目的 比较乳腺原发性印戒细胞癌与乳腺黏液腺癌的分子特点及预后.方法 对6例乳腺原发性印戒细胞癌患者和25例乳腺黏液腺癌患者的临床病理资料进行回顾性分析,比较其分子分型特点及生存情况.结果 乳腺原发性印戒细胞癌与乳腺黏液腺癌患者在发病年龄、肿瘤大小、TNM分期、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)表达及分子分型方面,差异均无统计学意义(P≥0.05);在淋巴结转移、Ki-67表达方面,差异有统计学意义(P﹤0.05).乳腺原发性印戒细胞癌与乳腺黏液腺癌患者的5年无病生存率分别为66.7%、80.0%.结论 乳腺原发性印戒细胞癌比乳腺黏液腺癌更具侵袭性,淋巴结转移率高,Ki-67表达水平高,预后差.

The molecular typing and prognosis of primary signet-ring cell carcinoma of the breast compared with mucinous breast cancer

Objective To compare the molecular typing and prognosis of primary signet-ring cell carcinoma(SRCC) of the breast and mucinous breast cancer(MBC).Method The clinical data of 6 patients diagnosed as SRCC and 25 pa-tients diagnosed as MBC were analyzed to compare the molecular typing and prognosis.Result There was no statistical-ly significant differences in age,tumor size,TNM stage,ER,PR,HER2 expression and molecular typing between the two groups(P≥0.05).Patients with SRCC showed more frequent lymphatic metastasis and higher Ki-67 index(P<0.05).The 5-year disease-free survival rates were 66.7% and 80.0% respectively in patients with SRCC and MBC. Conclusion SRCC is more aggressive than MBC,with more frequent lymphatic metastasis,higher Ki-67 index and worse prognosis.