干扰素与核苷(酸)类似物治疗慢性乙型肝炎对病人外周血调节性T细胞影响的差异研究

目的:探讨干扰素与核苷(酸)类似物治疗慢性乙型肝炎(CHB)对病人外周血调节性T细胞水平影响的差异.方法:10例接受干扰素治疗(干扰素组),13例接受核苷(酸)类似物治疗(核苷组)的CHB病人,治疗前及治疗过程中检测外周血CD4+CD25+CD127 low/-Tregs比例,并比较其差异性.结果:2组CD4+CD25+CD127 low/-Treg细胞均呈下降趋势,且差异有统计学意义(P<0.01).2组治疗开始时、治疗第3个月、第6个月差异均无统计学意义(P>0.05),治疗第9个月时,2组差异有统计学意义(P<0.05).结论:干扰素对CHB病人外周血CD4+CD25+CD127low/-Treg细胞水平变化的影响较核苷(酸)类似物更大,提示其可能具有远期免疫调节作用.

Study on the difference of peripheral blood regulatory T lymphocytes in chronic hepatitis B patients treated with antivirus

Objective:To investigate the difference and significance of the expression of regulatory T cells in peripheral blood of chronic hepatitis B(CHB) patients treated with interferon and nucleotide analogue. Methods:Ten CHB patients were treated with interferon( IFN group ) , and 13 CHB patients were treated with nucleoside ( acid ) analogue ( nucleoside group ) . The ratio of the peripheral blood CD4 +CD25 +CD127low/-Tregs was detected before and during treatment,and the difference of which was compared. Results:The CD4 + CD25 + CD127low/-Treg cells in two groups showed a downward trend, the difference between two groups was statistically significant(P<0. 01). The differences of cells at the beginning of treatment,and at 3 and 6 months of treatment between two groups were not statistically significant(P>0. 05),and the difference of which at 9 months of treatment between two groups was statistically significant(P<0. 05). Conclusions:The effect of interferon on the level of CD4 +CD25 +CD127low/-Treg cells in peripheral blood of patients with CHB is greater than that of nucleoside analogue,which suggests that it may have long-term immunomodulatory effects.