268例门诊癌痛患者镇痛药品用药分析

目的 分析评估某院近3年门诊癌痛患者麻醉镇痛药品的应用情况,探讨镇痛治疗策略,为临床合理应用该类药物提供依据.方法 选择门诊收治的268例癌痛患者为对象,记录其所用药品名称、用药量、使用天数、病种等,并进行逐份统计、整理、分析,比较治疗前后患者疼痛程度、生活质量等的差异.结果268例癌痛患者常用的阿片类镇痛药有5种,排序由高到低分别为盐酸羟考酮缓释片、芬太尼透皮贴剂、硫酸吗啡缓释片、盐酸吗啡片和磷酸可待因片.268例癌痛患者中,肺癌患者最多(26.5%);盐酸羟考酮缓释片的使用量最多;有36例患者用药时间超过1年.与治疗前相比,患者的痛感程度得到了缓解,疼痛数字评分(NRS)降低,卡氏功能状态评分(KPS)增加,治疗前后比较,差异均有统计学意义(P﹤0.05).结论 门诊癌痛治疗基本符合WHO癌痛治疗原则,但仍存在一定的问题,有待于进一步规范完善.

Analysis of analgesics use in 268 cases of outpatients with cancer pain

Objective To analyze the application of analgesics for cancer pain in outpatients in recent 3 years in our hospital, to discuss the analgesia strategy, and justify the reasonable clinical application. Method 268 cases of outpa-tients with cancer pain were recorded for the use of analgesics,including drug name,dosage,duration,and disease,all da-ta were statistically analyzed to compare the degree of pain and quality of life before and after treatment.Result There were 5 common opioid analgesics in these patients,with a descending frequency of oxycodone hydrochloride sustained re-lease tablets,fentanyl transdermal patch,morphine sulfate sustained release tablets,morphine hydrochloride tablets,and codeine tablets.Among the 268 patients with cancer pain,the majority were with lung cancer(26.5%);oxycodone hydro-chloride sustained-release tablets(OxyContin tablets)were the most common analgesics used;36 patients had been on an-algesics for more than 1 year.The degree of pain were decreased in these patients after treatment,which was reflected by lower numeric rating scale(NRS)score and higher Karnofsky performance score(KPS),and the differences before and af-ter treatment were of statistical significance (P<0.05). Conclusion The analgesia strategy in outpatients are generally consistent with WHO principles,but there are still some issues to be addressed.