纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性因子的干预研究

目的:纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性因子表达的影响.方法:选择符合非ST段抬高性心肌梗死诊断标准但未行冠脉介入治疗的病人80例(治疗组)及体检正常者40名(对照组)作为研究对象,观察2组血清炎性标志物高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6)的表达,再将80例非ST段抬高性心肌梗死病人随机分为常规治疗组和纤溶酶治疗组,观察纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性标志物hs-CRP、TNF-α、IL-6表达的影响.结果:入院时,观察组较对照组血清hs-CRP、TNF-α、IL-6明显升高(P<0.01).治疗后,纤溶酶治疗组较常规治疗组血清hs-CRP、TNF-α、IL-6明显降低(P<0.01).结论:非ST段抬高性心肌梗死涉及免疫炎症损伤,纤溶酶可以抑制免疫炎症因子表达.

Effect of fibrinolytic enzyme on inflammatory factors in non-ST-segment elevation myocardial infarction patients

Objective:To investigate the effects of fibrinolytic enzyme on inflammatory factors in non-surgical patients with non-ST-segment elevation myocardial infarction. Methods:Eighty patients with non-ST-segment elevation myocardial infarction and normal physical examinees were divided into the treatment group and control group,respectively.The serum levels of high-sensitivity c-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α) and interleukin 6(IL-6) in two groups were observed.Eighty patients with non-ST-segment elevation myocardial infarction were randomly subdivided into the routine treatment group and fibrinolytic enzyme treatment group,and the effects of fibrinolytic enzyme on the levels of hs-CRP,TNF-α and IL-6 were observed.Results:Compared with the control group,the serum levels of hs-CRP,TNF-α and IL-6 in observation group at admission significantly increased(P <0. 01). After treatment,the serum levels of hs-CRP,TNF-α and IL-6 in fibrinolytic enzyme treatment group significantly decreased compared with the routine treatment group(P < 0. 01). Conclusions:The non-ST-segment elevation myocardial infarction involves the immune inflammatory injury,and fibrinolytic enzyme can inhibit the expression of immune inflammatory factors.