胃癌初治患者术前外周血中性粒细胞和淋巴细胞比值与临床病理特征的关系及术后预后价值分析

目的 探讨外周血中性粒细胞和淋巴细胞比值(NLR)与胃癌初治患者临床病理特征的关系及其对术后预后的价值.方法 选取胃癌初治患者186例,采用系统性回顾法分析所有患者的临床资料及随访资料,记录患者的NLR值、性别、年龄、肿瘤情况及生存情况,并对不同NLR值患者的资料进行比较.结果 NLR升高组与NLR降低组患者的肿瘤浸润深度、淋巴结转移情况、肿瘤大小、病理分级、血清白蛋白水平及临床分期比较,差异有统计学意义(P﹤0.05);NLR升高组与NLR降低组患者的疗效比较,差异有统计学意义(P﹤0.05);通过Spearman等级相关分析可得,NLR值与胃癌患者的肿瘤浸润深度、淋巴结转移、临床分期、肿瘤大小及病理分级呈正相关(P﹤0.05);通过多因素Cox回归分析可得,NLR值、肿瘤浸润深度、淋巴结转移、临床分期、肿瘤大小及病理分级均为影响胃癌初治患者预后的独立危险因素(P﹤0.05).结论 NLR与胃癌初治患者的各项临床病理特征呈正相关,且为影响胃癌初治患者预后效果的独立危险因素,可作为临床上预测胃癌初治患者预后效果的有效指标之一.

Relationship between the neutrophil to lymphocyte ratio in peripheral blood of newly diagnosed patients with gastric cancer and the clinicopathological significance and prognostic value

Objective To investigate the relationship between the neutrophil to lymphocyte ratio (NLR) in peripheral blood and the clinicopathological features of patients with gastric cancer and its prognostic value. Method 186 patients with newly diagnosed gastric cancer were included in the study. The clinical profile and follow-up data of all patients were analyzed by systematic review, and the NLR values, gender, age, tumor status and survival of all patients were re-corded and were compared in patients with different NLR values. Result There were significant differences in regard of depth of tumor infiltration, lymph node metastases, tumor size, pathologic grade and serum albumin level between pa-tients with high and low NLR values (P<0.05), besides, the efficacy was also significantly different in these two groups of patients (P<0.05);by Spearman rank correlation analysis, it was found that, NLR was positively correlated with the depth of tumor infiltration, lymph node metastases, clinical stage, tumor size and pathologic grade (P<0.05); in multivariate Cox regression analysis, the NLR value, depth of tumor infiltration, lymph node metastases, clinical stage, tumor size and pathologic grade were independent prognostic factors of gastric cancer patients (P<0.05). Conclusion A positive correla-tion is detected between NLR and clinicopathological features of newly diagnosed gastric cancer patients, and it is an ef-fective independent risk factor for the prognosis of patients with newly diagnosed gastric cancer.