| 血管紧张素转化酶基因型与高血压病合并左心室肥厚的关系 |
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| 引用本文： | 沈丹,哈黛文,白春梅. 血管紧张素转化酶基因型与高血压病合并左心室肥厚的关系[J]. 中华医学遗传学杂志, 1998, 15(6): 364-366 |
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| 作者姓名： | 沈丹 哈黛文 白春梅 |
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| 作者单位： | 湖北医科大学附属第二医院老年病研究室 |
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| 摘 要： | 目的探讨中国人血管紧张素转化酶（ＡＣＥ）３种基因型（ＤＤ、ＩＤ、和Ｉ型）与高血压病合并左心室肥厚的关系。方法应用聚合酶链反应技术（ＰＣＲ）检测３３例高血压病左心室肥厚患者，５５例高血压病无心脑血管合并症患者，以及６２例正常人的ＡＣＥ基因型。结果高血压病左心室肥厚组ＤＤ基因型频率０．３９４和Ｄ等位基因频率０．６０６显著高于正常对照组的０．１２９和０．３８７（Ｐ＜０．０１），以及高血压无心脏血管合并症组的０．１２８和０．４００（Ｐ＜０．０１）。结论ＡＣＥ基因缺失型可能是高血压病左心室肥厚发病的重要危险因素。
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| 关 键 词： | 血管紧张素转化酶 遗传学 左心室肥厚 高血压病 |
RELATIONSHIP BETWEEN GENOTYPE OF ANGIOTENSIN CONVERTING ENZYME GENE AND LEFT VENTRICULAR HYPERTROPHY IN CHINESE HYPERTENSIVES |
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| Shen Dan ,Ha Daiwen,Bai Chunmei. RELATIONSHIP BETWEEN GENOTYPE OF ANGIOTENSIN CONVERTING ENZYME GENE AND LEFT VENTRICULAR HYPERTROPHY IN CHINESE HYPERTENSIVES[J]. Chinese journal of medical genetics, 1998, 15(6): 364-366 |
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| Authors: | Shen Dan Ha Daiwen Bai Chunmei |
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| Affiliation: | Shen Dan *,Ha Daiwen,Bai Chunmei.* Department of Gerontology,Second Affiliated Hospital,Hubei Medical University,Wuhan,430071 P.R.China |
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| Abstract: | Objective To search into the relationship between genotype of angiotensin converting enzyme(ACE) gene and left ventricular hypertrophy(LVH) in Chinese hypertensives.Methods ACE genotyping with polymerase chain reaction(PCR) was performed in 33 unrelated hypertensives with LVH, 55 hypertensives without cardio cerebrovascular disseases and 62 healthy controls.Results The frequencies of DD genotype(0.394) and deletion allele(0.606) among hypertensives with LVH were significantly higher than those (0.129 and 0.387)among controls and those (0.128 and 0.400) among hypertensives without cardio cerebrovascular diseases.Conclusion A deletion polymorphism of ACE gene probably increases the risk for left ventricular hypertrophy in Chinese hypertensives. |
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| Keywords: | Angiotensin converting enzyme Genetics Left ventricular hypertrophy Hypertension |
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