蒜油抗高原缺氧效应初探

目的:探讨蒜油对急进模拟高原大鼠的抗缺氧效应。方法:低压氧舱复制大鼠急进高原模型,观察蒜油对血气、血液动力学、自由基等指标的影响。结果:蒜油提高了大鼠急进高原模型动脉血氧分压(PaO_2)、血氧饱和度(SaO_2),P<0.05;降低了肺动脉压(PAP),P<0.01;主动脉收缩压(SAP)、左室收缩压(LVSP)、左心室压力最大上升速率(+dp/dt_(max)),P<0.001;增加了血浆超氧化物歧化酶(SOD)含量,P<0.001。结论:蒜油具有抗高原缺氧效应,其作用可能是通过降低肺动脉高压(HPAP)及心肌氧耗,纠正自由基代谢失衡来实现。大蒜是较有潜力的抗高原缺氧药物。

INITIAL INVESTIGATION OF EFFECTS OF ANTI - HYPOXIA OF GARLIC - OIL AT HIGH ALTITUDE

Objective: To investigate the effects of acute anti - hypoxia of garlic - oil at high altitude in rats. Method: 24 Wister rats had been divided into three groups, i.e. nomoxic group, hypoxic group and garlic ?oil group. After the animals were exposed to hypoxic environment (equal to 5000m altitude) in low pressure chamber for three days, their blood - gas, hemodynamics and metabolism of oxygen free radicals were measured. Result: The arterial oxygen partial pressure (PaO2), oxygen saturation (SaO2) , and superoxide dismutase (SOD) content in garlic - oil group were higher than those in hypoxic group (p < 0.05 - 0.001) . The pulmonary arterial pressure (PAP) , systolic aortic pressure (SAP) , left ventricular peak - value systolic pressure (LVSP) , maximal speed of pressure increase in left peak during systolic pressure ( + dp/dtmax) and malondialdehyde (MDA) content in garlic - oil group were lower than those in the hypoxic group. Conclusion: It is suggested that garlic - oil can reduce the effects of acute hypoxia on rats by improving PaO2, SaO2, hemodynarnics and metabolism of oxygen free radicals.