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Chlorambucil overdose: Accidental ingestion of an antineoplastic drug |
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| Authors: | Sharon A. Vandenberg B.S. R.Ph. Kenneth Kulig M.D. David G. Spoerke M.S. R.Ph. Alan H. Hall M.D. Valerie J. Bailie M.D. Barry H. Rumack M.D. |
| Affiliation: | a University of Colorado Health Sciences Center, USA b Rocky Mountain Poison & Drug Center, Denver, Colorado, USA c Panhandle Pediatric Clinic, Scottsbluff, Nebraska, USA |
| Abstract: | A 22-month-old, 10 kg child ingested 32 mg of chlorambucil and developed irritability, myoclonic-like muscle jerks, an exaggerated startle reflex, vomiting, and EEG changes within a few hours. The neurologic symptoms improved overnight, and the patient was discharged at about 28 hours postingestion. During the three weeks of follow-up, mild bone marrow suppression occurred and resolved. A normal EEG was reported at 33 weeks postingestion. |
| Keywords: | Author Keywords: chlorambucil overdose antineoplastic Leukeran |
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