| NEGATIVE REGULATORY EFFECT OF SOMATOSTATIN ON EXPERIMENTAL RAT HEPATIC FIBROSIS |
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| 引用本文： | PAN Qin LI Ding-guo LU Han-ming XU Qin-fang LU Liang-yong ZHANG Wen-zhu. NEGATIVE REGULATORY EFFECT OF SOMATOSTATIN ON EXPERIMENTAL RAT HEPATIC FIBROSIS[J]. 上海第二医科大学学报, 2008, 20(1): 1-6,12 |
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| 作者姓名： | PAN Qin LI Ding-guo LU Han-ming XU Qin-fang LU Liang-yong ZHANG Wen-zhu |
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| 作者单位： | PAN Qin（Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China） LI Ding-guo（Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China） LU Han-ming（Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China） XU Qin-fang（Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China） LU Liang-yong（Research Center of Hepatic Dieases , Nanjing Military Command, Shanghai 200233, China） ZHANG Wen-zhu（Department of Pathology, Xinhna Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092,China） |
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| 基金项目： | 上海市科委科研发展项目 |
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| 摘 要： | Objective To clarify the actions of somatostatin （SST） on the hepatic fibrogenesis in experimental rats. Methods Seventy five Sprague-Dawley rats were divided into 5 groups at random, including normal control, model control, SST-treated model groups of high, medium and low doses （200 μg·kg^-1·d^-1 , 100μg·kg^ 1 ·d^-1and 50 μg·kg^ 1 ·d^-1, respectively） （ n = 15, in each group）. All rats, except for the normal controls, were injected with 40% carbon tetrachloride （ CCI4 ） subcutaneously for 8 weeks to establish hepatic fibrosis. Meanwhile, rats of SST-treated model groups were given different doses of SST twice a day in the same way. Then the liver function, serum levels of hyaluronic acid （HA）, laminin （ LM） , and collagen type IV （CIV） were tested. The collagen types I and III, and pathological changes in liver tissue were assessed. Results Being compared with the model control group, SST-treated groups, especially the medium and low dose ones, exhibited significantly improved indices of liver function, including alanine minotransferase （ALT）, aspartate aminotrans- ferase （AST）, albumin （ALB）, total bilirubin （TBIL） and alkaline phosphatase （ALP）. Markedly lowered expres- sion of serum HA, LM and tissular collagen types I, III were also detected radioimmunologically and immunohisto- chemically in the low dose SST-treated model group. Moreover, pathological findings, such as lessened fibrous septa, decreased hepatic stellate cells （HSCs）, alleviated hepatic steatosis and attenuated inflammation, confirmed the significant improvement in fibrotic degree under the treatment of low dose rather than other doses of SST. Conclusion SST exerts the negative modulatory effect on hepatic fibrosis with a pathophysiological basis of extra- cellular matrixes （ECM） decreasing and hepatocyte protection. Low dose of SST （50 μg·kg^ 1 ·d^-1 ） maY be the optimum one among all doses.
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| 关 键 词： | 肝纤维化 生长激素抑制素 肝功能 病理学 |
NEGATIVE REGULATORY EFFECT OF SOMATOSTATIN ON EXPERIMENTAL RAT HEPATIC FIBROSIS |
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| PAN Qin,LI Ding-guo,LU Han-ming,XU Qin-fang,LU Liang-yong,ZHANG Wen-zhu. NEGATIVE REGULATORY EFFECT OF SOMATOSTATIN ON EXPERIMENTAL RAT HEPATIC FIBROSIS[J]. Journal of Shanghai Second Medical University(Foreign Language Edition), 2008, 20(1): 1-6,12 |
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| Authors: | PAN Qin LI Ding-guo LU Han-ming XU Qin-fang LU Liang-yong ZHANG Wen-zhu |
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| Affiliation: | [1]Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai200092, China; [2]Research Center of Hepatic Diseases, Nanjing Military Command, Shanghai 200233, China; [3]Department of Pathology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092,China |
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| Abstract: | somatostatin hepatic fibrosis liver function extracellular matrix pathology |
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| Keywords: | somatostatin hepatic fibrosis liver function extracellular matrix pathology |
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