| RGS蛋白对阿片受体-腺苷酸环化酶的调节及阿片受体对钾通道调节的研究进展 |
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| 引用本文： | 张德昌,叶菜英,陆久怡,谢志华,李志松,郭磊,于小莉,李娟,杨惠芬.RGS蛋白对阿片受体-腺苷酸环化酶的调节及阿片受体对钾通道调节的研究进展[J].中国药物依赖性杂志,2006,15(3):173-176. |
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| 作者姓名： | 张德昌 叶菜英 陆久怡 谢志华 李志松 郭磊 于小莉 李娟 杨惠芬 |
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| 作者单位： | 中国医学科学院基础医学研究所药理学系,北京,100005 |
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| 摘 要： | 本文介绍了RGS蛋白对阿片受体-腺苷酸环化酶活性的调节;阿片受体长期激活对细胞内钙离子、细胞浆酸碱度以及线粒体膜电势的影响;以及阿片受体不通过G蛋白对细胞膜外向整流钾通道的调节机理。
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| 关 键 词： | RGS蛋白 阿片受体 线粒体膜电势 外向整流钾通道 |
| 收稿时间： | 2006-05-08 |
| 修稿时间： | 2006年5月8日 |
THE PROGRESS ABOUT THE MODULATION OF RGS PROTEIN ON OPIOID RECEPTOR- ADENYL CYCLASE AND THE INFLUENCE OF OPIOID RECEPTOR ON POTASSIUM CHANNEL |
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| ZHANG Dechang,YE Caiying,LU Jiuyi,XIE Zhihua,LI Zhisong,GUO Lei,YU Xiaoli,LI Juan,YANG Huifen.THE PROGRESS ABOUT THE MODULATION OF RGS PROTEIN ON OPIOID RECEPTOR- ADENYL CYCLASE AND THE INFLUENCE OF OPIOID RECEPTOR ON POTASSIUM CHANNEL[J].Chinese Journal of Drug Dependence,2006,15(3):173-176. |
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| Authors: | ZHANG Dechang YE Caiying LU Jiuyi XIE Zhihua LI Zhisong GUO Lei YU Xiaoli LI Juan YANG Huifen |
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| Institution: | Department of Pharmacology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing, 100005 |
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| Abstract: | The modulation of RGS protein on opioid receptor and adenyl cyclase; the influence on inner cell calcium, the acidity in cell plasma and the mitochondrial membrane potential after long term activation of opioid receptor; the possible mechanism about the modulatory effect of opioid receptor on outwardly rectifying potassium channel which were independent of G protein were talked about in this article. |
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| Keywords: | RGS protein opioid receptor mitochondrial membrane potential outwardly rectifying potassium channel |
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