硫酸镁对术后布托啡诺患者自控静脉镇痛效果的影响

目的评价硫酸镁对布托啡诺患者自控静脉术后镇痛（PCIA）效果的影响。方法 50例ASAⅠ-Ⅱ级择期上腹部手术患者,随机分为布托啡诺组（B组：0.15 g/L布托啡诺）和硫酸镁复合布托啡诺组（BM组：0.15 g/L布托啡诺和25 g/L硫酸镁混合液）。手术结束时接镇痛泵,参数设置：负荷量1 ml,背景输注2 ml/h,指定剂量1 ml,锁定时间15 min。观察并记录PCIA后1、4、8、16、24 h患者疼痛评分、镇静程度和镇痛药消耗量,记录术后胃肠功能恢复时间,观察术后2天恶心呕吐的发生情况。结果与B组相比,BM组24 h的镇痛药量减少（P〈0.05）,视觉模拟评分（Visual Analogue Scale,VAS）降低（P〈0.05）,术后胃肠功能恢复时间、恶心呕吐发生率2组差别无统计学意义（P〉0.05）。结论硫酸镁增强布托啡诺患者自控静脉术后镇痛的效果。

Effects of magnesium sulphate on the efficacy of patient-controlled intravenous analgesia with butorphanol

Objective To evaluate the effects of magnesium sulphate on the efficacy of postoperative patient-controlled intravenous analgesia（PCIA） with butorphanol.Methods Fifty ASA I or ASA II patients were randomly allocated into 2 groups（n=25 each）： butorphanol group（group B） and combination of magnesium sulphate group（group BM）.At the end of the operation,the patients underwent PCIA at a loading dose of 1 ml,background infusion of 2 ml/h,bolus of 1 ml and lockout time of 15 min.Group B received butorphanol at 0.15 g/L and group BM received butorphanol of 0.15 g/L in combination with magnesium sulphate of 25 g/L.The Visual Analogue Scale（VAS） score,sedative degree,nausea and vomiting and the consumption of and analgesic drugs were recorded at 1,4,8,16,24 h after PCIA.The gastrointestinal function recovery time was recorded.Results Compared with group B,the VAS score and the consumption of analgesic drugs significantly decreased（P0.05）.There were no significant differences between the two groups as to sedation,nausea and vomiting and gastrointestinal function recovery time.Conclusion Magnesium sulphate can ameliorate the postoperative PCIA with butorphanol.